Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Book ChapterDOI
Genetics of Cleft Lip and Cleft Palate: Perspectives in Surgery Management and Outcome
Gerson Shigeru Kobayashi,Luciano Abreu Brito,Joanna Goes Castro Meira,Lucas Alvizi,Maria Rita Passos-Bueno +4 more
TL;DR: Understanding the etiology of CLP is of utmost importance, as it may lead to the development or improvement of preventive and therapeutic strategies.
Journal ArticleDOI
The effects of IRF6 rs2235373 polymorphism on mRNA expression changes in non-syndromic cleft lip and palate with various phenotypes
Saskia L. Nasroen,Ani Melani Maskoen,Hardisiswo Soedjana,Eky Setiawan Soeria Soemantri,Dany Hilmanto +4 more
TL;DR: The IRF6 rs2235373 polymorphism of TT genotype tends to cause mRNA overexpression in NS CU CLP, and CT genotype tend to cause RNA underexpression on mRNA expression changes in NS CB CLP.
Journal ArticleDOI
Repair of cleft palate by rotation–transposition of the two mucoperiosteal flaps: can this reduce the incidence of postoperative fistula?
TL;DR: The modified technique to rotate one of the mucoperiosteal flaps backward to fill the midline gap at the point of maximum tension to be recommended as an alternative to the standard von Langenbeck cleft palate repair especially with wide Cleft palate or when there is much tension when suturing the oral mucosa.
Journal ArticleDOI
Molecular Screening of VAX1 Gene Polymorphisms Uncovered the Genetic Heterogeneity of Nonsyndromic Orofacial Cleft Among Saudi Arabian Patients.
Heba J. Sabbagh,Innes Npt,Edris Ahmed S,Azeez Butali,Alnamnakani Ea,Rabah Sm,Mustafa A. Hamdan,Nasir Al-Hamlan,Fatma D. Abdulhameed,Hassan Mha,Al Mahdi Hb,Najlaa M. Alamoudi,Jumana Y. Al-Aama,Alaki Sm,Peter A. Mossey +14 more
TL;DR: This is the first study to find a relationship between these two loci on 10q25 (rs4752028 and rs7078160) and NSOFC in a population with high levels of consanguinity.
DissertationDOI
Epidemiology of choanal atresia - the National Birth Defects Prevention Study
TL;DR: Overall, case infants compared to control infants were more likely to be female, preterm, and a multiple birth, and odds of high maternal zinc and vitamin B-12 intake and maternal periconceptional exposure to passive cigarette smoke were significantly elevated.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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