Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Frequency of pharyngoplasty after primary repair of cleft palate in northern Finland
TL;DR: The majority of patients undergoing primary palatal repair do not need secondary pharyngoplasty and the rate of secondary surgery was significantly higher for girls than for boys, and cleft severity was significant factors for secondary surgery.
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CAD/CAM silicone simulator for teaching cheiloplasty: description of the technique
TL;DR: A CAD/CAM silicone simulator is described, which was made using several maxillofacial prosthetic techniques and proved its worth in teaching junior surgeons how to do a cheiloplasty.
Journal ArticleDOI
Craniofacial malformations and the orthodontist
TL;DR: The focus is on cleft lip and palate, followed by more complex deformities including craniosynostosis and craniofacial microsomia, and the role of the orthodontist in their management.
Journal ArticleDOI
Classifying Common Oral Clefts: A New Approach After Descriptive Registration
TL;DR: A new classification based on the pathoembryological events that ultimately result in various subphenotypes of common oral clefts was tested, providing new cleft subgroups that may be used for clinical and fundamental research.
Journal ArticleDOI
BMP4 Was Associated with NSCL/P in an Asian Population
Qianqian Chen,Hong Wang,Jacqueline B. Hetmanski,Tianxiao Zhang,Ingo Ruczinski,Holger Schwender,Kung Yee Liang,M. Daniele Fallin,Richard J. Redett,Gerald V. Raymond,Yah-Huei Wu Chou,Philip Kuo Ting Chen,Vincent Yeow,Samuel S. Chong,Felicia S.H. Cheah,Ethylin Wang Jabs,Ethylin Wang Jabs,Alan F. Scott,Terri H. Beaty +18 more
TL;DR: Test for possible association between markers in and around the BMP4 gene and NSCL/P in Asian and Maryland trios provided further evidence of association.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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