Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family
Nevena Cvjetkovic,Lorena Maili,Katelyn S. Weymouth,Katelyn S. Weymouth,S. Shahrukh Hashmi,John B. Mulliken,Jacek Topczewski,Ariadne Letra,Qiuping Yuan,Susan H. Blanton,Eric C. Swindell,Jacqueline T. Hecht +11 more
TL;DR: It is hypothesized that alteration in FZD6 expression contributes to NSCLP in this family by perturbing the WNT signaling pathway, which is involved in craniofacial development, including midfacial formation and upper labial fusion.
Journal ArticleDOI
TGF-β Signaling and the Epithelial-Mesenchymal Transition during Palatal Fusion
TL;DR: The current understanding on the role of TGF-β signaling, and specifically its association with MEE cell fate during palatal fusion, is summarized and the new insights in the fate of MEE cells in the midline epithelial seam (MES) during the palate fusion process are discussed.
Journal ArticleDOI
Oral Clefting in China Over the Last Decade: 205,679 Patients
TL;DR: The epidemiology and surgical procedures performed on the largest reported cohort of individuals with clefting in China, which reports the largest cohort of cleft patients treated by surgeons to date, generally follows trends previously reported in China and developed countries.
Journal ArticleDOI
Analysis of human soft palate morphogenesis supports regional regulation of palatal fusion.
TL;DR: The results are consistent with the soft palate following a developmentally more rapid program of fusion than the hard palate, and the two regions of the palate appear to be independently regulated and have their own internal clocks regulating the timing of seam removal.
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A Study on Environmental Factors for Nonsyndromic Cleft Lip and/or Palate.
TL;DR: The proper amount of folic acid, the appropriate age of childbearing, and the high education were the protective factors of NSCL/P, whereas family history, abortion history, drug use during pregnancy, maternal tobacco and alcohol, and maternal stress were the risk factors for NSLI/P in Yantai District, China.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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