Journal ArticleDOI
Cleft lip and palate
Reads0
Chats0
TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
More filters
Journal ArticleDOI
Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice.
Hiroki Yoshioka,Aimin Li,Akiko Suzuki,Sai Shankar Ramakrishnan,Zhongming Zhao,Zhongming Zhao,Junichi Iwata,Junichi Iwata +7 more
TL;DR: Zhang et al. as discussed by the authors identified regulatory networks of microRNAs (miRNAs), transcriptional factors (TFs), and non-TF genes associated with cleft lip (CL) that are conserved in humans and mice.
Journal ArticleDOI
Ecuadorian Spanish translation and validation of the VELO quality of life instrument.
Lucille Ridgell,Christina T. Roth,Mikaela Bow,Rayyan Hares-Helou,Karina Mayorga Arias,Sarah Hatch Pollard,Usama S Hamdan,Travis Tate Tollefson,Jonathan R. Skirko +8 more
TL;DR: The VELO-Ec is a valid and reliable measure of VPI-related quality of life, useful to clinicians and researchers treating Ecuadorian CP patients, especially in areas with limited resources such as on humanitarian missions.
Book ChapterDOI
The Logical Combinatorial Approach Applied to Pattern Recognition in Medicine
TL;DR: The objective of this work is to show the usefulness of the logical combinatorial approach to solve problems of pattern recognition in Medicine by illustrating three case studies: the differential diagnosis of Glaucoma, a method for comparing somatotypes, and the prognosis of rehabilitation of patients with cleft lip and palate.
Journal ArticleDOI
Osteopontin, osteocalcin, and osteoprotegerin expression in human tissue affected by cleft lip and palate
L. Smane,M. Pilmane +1 more
TL;DR: Few OPG-positive osteocytes in the bone tissue implicate the disregulation of osteoclast differentiation, maturation, and activity, but few OPN-containing cells may prove the common disregard of bone remodelling during cleft morphopathogenesis.
Journal ArticleDOI
Birth prevalence of orofacial clefts among perinatal infants: A register-based study in Bao'an district, Shenzhen, China.
TL;DR: A register‐based study to estimate the birth prevalence of orofacial clefts in Bao'an district, Shenzhen, China and results are considerable varied.
References
More filters
Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
Related Papers (5)
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo Ting Chen,Hong Wang,Xiaoqian Ye,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Mads Melbye,Kimberly F. Doheny,Elizabeth W. Pugh,Hua Ling,Eduardo E. Castilla,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,James M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +55 more
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
Stefanie Birnbaum,Stefanie Birnbaum,Kerstin U. Ludwig,Heiko Reutter,Stefan Herms,Michael Steffens,Michele Rubini,Carlotta Baluardo,Melissa Ferrian,Nilma Almeida de Assis,Margrieta A. Alblas,Sandra Barth,Jan Freudenberg,Carola Lauster,Gül Schmidt,Martin Scheer,Bert Braumann,Stefaan J. Bergé,Rudolf H. Reich,Franziska Schiefke,Alexander Hemprich,Simone Pötzsch,Régine P.M. Steegers-Theunissen,Bernd Pötzsch,Susanne Moebus,Bernhard Horsthemke,Franz-Josef Kramer,Thomas F. Wienker,Peter A. Mossey,Peter Propping,Sven Cichon,Per Hoffmann,Michael Knapp,Markus M. Nöthen,Elisabeth Mangold +34 more
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Elisabeth Mangold,Kerstin U. Ludwig,Stefanie Birnbaum,Carlotta Baluardo,Melissa Ferrian,Stefan Herms,Heiko Reutter,Nilma Almeida de Assis,Taofik Al Chawa,Manuel Mattheisen,Michael Steffens,Sandra Barth,Nadine Kluck,Anna Paul,Jessica Becker,Carola Lauster,Gül Schmidt,Bert Braumann,Martin Scheer,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Susanne Moebus,Michael Krawczak,Stefan Schreiber,Thomas Meitinger,Hans Erich Wichmann,Régine P.M. Steegers-Theunissen,Franz Josef Kramer,Sven Cichon,Peter Propping,Thomas F. Wienker,Michael Knapp,Michele Rubini,Peter A. Mossey,Per Hoffmann,Markus M. Nöthen +37 more