Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Evidence of Olfactory Deficits in Isolated Orofacial Clefting
TL;DR: The aim of this study is to investigate the prevalence of olfactory deficits in cases with different types of orofacial clefting and their unaffected first-degree relatives and to help in understanding the genetic etiology.
Journal ArticleDOI
Histologic Aspect of the Curved Vomerine Mucosa in Cleft Lip and Palate.
Benito K. Benitez,Benito K. Benitez,Andrzej Brudnicki,Prasad Nalabothu,Prasad Nalabothu,Jeannette A. von Jackowski,Elisabeth Bruder,Andreas A. Mueller,Andreas A. Mueller +8 more
TL;DR: In this paper, common surgical techniques aim to turn the entire vomerine mucosa with vomer flaps either to the oral side or to the nasal side, and the latter approach is widely performed due to the simila...
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Parental Risk Factors and Child Birth Data in a Matched Year and Sex Group Cleft Population: A Case-Control Study.
TL;DR: In this paper, the authors evaluated the effect of parental age and mothers' body mass index on the risk of having an orofacial cleft child, in a matched year and sex group (cleft/healthy control).
Journal ArticleDOI
Assessing agreement between preclinical magnetic resonance imaging and histology: An evaluation of their image qualities and quantitative results.
Cindy Elschner,P. Korn,Maria Hauptstock,Matthias C. Schulz,Ursula Range,Diana Jünger,Ulrich Scheler +6 more
TL;DR: A detailed method comparison between histology and magnetic resonance imaging is demonstrated and it is demonstrated that method comparisons not always need the use of an independent animal study, additionally.
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Choosing a Multidisciplinary Cleft and Craniofacial Team: Medical, Surgical, and Social Considerations.
TL;DR: In this paper , the authors summarize medical, surgical, and social considerations for selecting a cleft and craniofacial team to optimize patient outcomes and the family/caregiver experience.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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