Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Maternal arsenic exposure and nonsyndromic orofacial clefts
Jonathan Suhl,Stephanie A. Leonard,Peter J. Weyer,Anthony Rhoads,Anna Maria Siega-Riz,T. Renée Anthony,Trudy L. Burns,Kristin M Conway,Peter H. Langlois,Paul A. Romitti +9 more
TL;DR: Results should be interpreted cautiously, and continued research using improved exposure assessment methodologies is recommended, but the need for a comprehensive examination of major sources of arsenic exposure and OFCs in humans is supported.
Journal ArticleDOI
Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo.
TL;DR: This is the first report showing that gelatinases might contribute to tissue remodeling during early stages of palatal shelf elevation and formation of the nasopharynx in mammalian embryos.
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Assessing the Compliance of Randomized Controlled Trials Published in Craniofacial Surgery Journals With the CONSORT Statement.
Mimi R. Borrelli,Reem Farwana,Tom W. Andrew,Maria Chicco,Munir Abukhder,Dima Mobarak,Rachel Thavayogan,Riaz Agha,Thomas E. Pidgeon +8 more
TL;DR: The compliance of craniofacial surgery RCTs with the CONSORT statement requires improvement, and areas in need are identified, and methods to improve reporting transparency, are discussed.
Journal ArticleDOI
A practical prenatal ultrasound classification system for common oral clefts
Wiesje Maarse,Chantal Wb Boonacker,Corstiaan C. Breugem,Moshe Kon,Gwendolyn T. R. Manten,Aebele B. Mink van der Molen +5 more
TL;DR: The aim is to introduce and validate a new oral cleft classification system based on prenatal ultrasound for use by professionals in daily practice.
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Global Burden of Orofacial Clefts and the World Surgical Workforce
Benjamin B Massenburg,Richard A Hopper,Christopher S Crowe,Shane D Morrison,Nivaldo Alonso,Mert Calis,Peter Donkor,Prasetyanugraheni Kreshanti,Jie Yuan +8 more
TL;DR: In this article, the authors estimated the prevalence and disease burden of orofacial clefting from 1990 to 2017 in 195 countries using the Global Burden of Disease methodology and found that this burden falls disproportionately on the countries with the smallest surgical workforce or lowest Socio-Demographic Index, rather than those with the highest prevalence of disease.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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