Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients.
Tiit Nikopensius,Stefanie Birnbaum,Kerstin U. Ludwig,Triin Jagomägi,Mare Saag,Stefan Herms,Michael Knapp,Per Hoffmann,Markus M. Nöthen,Andres Metspalu,Andres Metspalu,Elisabeth Mangold +11 more
TL;DR: A significant association was observed for rs7078160 at chromosome 10q25, which confirms the association of this locus with NSCL/P in the Baltic population and investigates whether these newly detected loci confer similar effects in the North-East European Baltic population.
Journal ArticleDOI
The impact of cleft lip and/or palate on parental quality of life : a pilot study
TL;DR: This cross-sectional study confirms that having a child with CL/CP/CLP impacts the parental QoL and future development of effective screening tools and identification of subgroups at risk are confirmed.
Journal ArticleDOI
Birth prevalence of Robin sequence in the Netherlands from 2000‐2010: a retrospective population‐based study in a large Dutch cohort and review of the literature
Emma C. Paes,Daan P. F. van Nunen,Hanneke Basart,J. Peter W. Don Griot,Johanna M. van Hagen,Chantal M.A.M. van der Horst,Marie José H. Van Den Boogaard,Corstiaan C. Breugem +7 more
TL;DR: RS was estimated to occur in a third of the CP population and patients with RS had a more severe cleft grade than the general CP population, which was higher than reported for most other countries when similar diagnostic criteria were used.
Journal ArticleDOI
Comparative Volume Analysis of Alveolar Defects by 3D Simulation.
Pang-Yun Chou,Rafael Denadai,Rami R. Hallac,Sarayuth Dumrongwongsiri,Wei-Chuan Hsieh,Betty Cj. Pai,Lun-Jou Lo +6 more
TL;DR: The volume of unilateral and bilateral alveolar cleft defects can be equally quantified by 3D-printed and virtual surgical simulation methods and provides alveolars defect-specific volumes which can serve as a reference for planning and execution ofAlveolar bone graft surgery.
Journal ArticleDOI
School performance for children with cleft lip and palate: a population‐based study
Jane C. Bell,Camille Raynes-Greenow,Robin M. Turner,Carol Bower,Carol Bower,A. Dodson,W. Nicholls,Natasha Nassar +7 more
TL;DR: Children born with orofacial cleft, particularly children with CPO, should be monitored to identify learning difficulties early, to enable intervention to maximize school attainment.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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