Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Waiting Too Long: The Contribution of Delayed Surgical Access to Pediatric Disease Burden in Somaliland
Emily R. Smith,Emily R. Smith,Tessa Concepcion,Mark G. Shrime,Mark G. Shrime,Kelli Niemeier,Mubarak Mohamed,Shugri Dahir,Edna Adan Ismail,Dan Poenaru,Henry E. Rice,Global Initiative for Children’s Surgery +11 more
TL;DR: Estimating the burden of delayed surgical care with avertable delayed DALYs offers a powerful tool for estimating the costs and benefits of interventions to improve the quality of surgical care.
Journal ArticleDOI
Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-β/Smad signaling.
Xing Li,Zhang Lin,Xinjuan Yin,Zhan Gao,Huanhuan Zhang,Xiaozhuan Liu,Xinjuan Pan,Ning Li,Zengli Yu +8 more
TL;DR: Findings suggested that RA overexposure inhibited cell proliferation and disrupted the ECM network through down-regulation of TGF-β/Smad pathway.
Journal ArticleDOI
3-D shape analysis of palatal surface in patients with unilateral complete cleft lip and palate
TL;DR: The aim of this study was to evaluate palatal morphology and variability in patients with UCLP compared with Czech norms using methods of geometric morphometrics and found that the variability of palatal shape in UclP patients was greater than that in nonclefted palates.
Journal ArticleDOI
Presurgical cleft lip and palate orthopedics: an overview
TL;DR: It is believed that PSO treatment, specifically nasoalveolar molding, does help to approximate the segments of the cleft maxilla and does reduce the intersegment space in readiness for the surgical closure of cleft sites.
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Autogenous Bone Graft Versus Bovine Bone Graft in Association With Platelet-Rich Plasma for the Reconstruction of Alveolar Clefts: A Pilot Study.
Bruno Torres Bezerra,John Nadson Andrade Pinho,Fabrício Eneas Diniz Figueiredo,José Renato Moraes Carvalho Barreto Brandão,Lucas Celestino Guerzet Ayres,Luiz Carlos Ferreira da Silva +5 more
TL;DR: Bovine grafts associated with PRP are a good option for the reconstruction of alveolar clefts and provide good results such as autologous bone grafts.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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