Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Clinical spectrum and pleiotropic nature of CDH1 germline mutations
Joana Figueiredo,Soraia Melo,Patrícia Carneiro,Ana Margarida Moreira,Maria Sofia Fernandes,Ana Sofia Ribeiro,Parry Guilford,Joana Paredes,Raquel Seruca +8 more
TL;DR: A comprehensive analysis of CDH1-associated disorders and germline alterations found in each trait is brought together, providing important insights into the biological mechanisms underlying E-cadherin’s pleiotropic effects.
Journal ArticleDOI
Is International Volunteer Surgery for Cleft Lip and Cleft Palate a Cost-Effective and Justifiable Intervention? A Case Study from East Asia
TL;DR: The contribution of the international volunteer surgical team to building in-country capacity is notable and was achieved primarily through training Vietnamese surgeons during the mission trips and through sending these surgeons to Korea for training.
Journal ArticleDOI
Systematic Review and Meta-Analysis of the Birth Prevalence of Orofacial Clefts in Low- and Middle-Income Countries.
Ayesha Kadir,Peter A. Mossey,Hannah Blencowe,Sowmiya Moorthie,Joy E Lawn,Pierpaolo Mastroiacovo,Bernadette Modell +6 more
TL;DR: In LMICs, approximately 1 in every 730 children is born with CL/P, and future research should use a standard classification system and standard criteria for data collection and presentation to optimize comparability across settings.
Journal ArticleDOI
Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects
Lucas Alvizi,Xiayi Ke,Luciano Abreu Brito,Rimante Seselgyte,Gudrun E. Moore,Philip Stanier,Maria Rita Passos-Bueno +6 more
TL;DR: The association of methylation at specific genomic locations as contributing factors to both non-familial and familial NSCLP and altered DNA methylation may be a second hit contributing to penetrance is demonstrated.
Journal ArticleDOI
Prevalence of orofacial clefts in Nigeria.
Azeez Butali,Wasiu Lanre Adeyemo,Peter A. Mossey,Hector Oladapo Olasoji,I.I. Onah,A.R Adebola,Efunkoya,A. Akintububo,Olutayo James,OO Adeosun,M.O. Ogunlewe,A L Ladeinde,B.O. Mofikoya,Michael O. Adeyemi,O.A. Ekhaguere,Christian Ibezi Emeka,T.A. Awoyale +16 more
TL;DR: The present study emphasizes the need for birth defects registries in developing countries in order to estimate the exact prevalence of birth defects including orofacial clefts.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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