Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Characterization of deletions in a cohort with cleft lip and palate
TL;DR: This cohort helps to support previous literature describing patients with orofacial clefts and microdeletions, along with presenting rarer associations, including an individual with a 12q21.1 deletion and cardiofaciocutaneous-like phenotype.
Journal ArticleDOI
Communication and cognition profiles in parents of children with nonsyndromic cleft lip and/or palate.
TL;DR: Having significantly fewer years of schooling in the P-CLP group could be suggestive of an increased risk of communication and cognitive difficulties these parents face, and the potential difficulties their children with CLP may encounter.
Journal ArticleDOI
Normal emotion regulation in adults with cleft lip and palate: an exploratory study.
Volker Gassling,Henrik Kessler,Marcus O. Klein,Anna-Maria Detjen,Bernd Koos,Kerstin Limbrecht-Ecklundt,Harald C. Traue,Jörg Wiltfang,Wolf-Dieter Gerber +8 more
TL;DR: The findings suggest that individuals with an orofacial cleft show undisturbed emotion regulation and recognition, which may be explained by the strong biological basis of facial emotion recognition and regulation as well as by the healthy emotional resilience and social functioning of CLP patients.
Journal ArticleDOI
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study
Anne L. Depla,Corstiaan C. Breugem,Chantal M.A.M. van der Horst,Roel de Heus,Marie-José H. van den Boogaard,Saskia M. Maas,Eva Pajkrt,Mireille N. Bekker +7 more
TL;DR: The incidence and outcome of idiopathic polyhydramnios in isolated OC pregnancies is assessed and it is suggested to be associated with oral clefts (OCs) due to swallowing problems.
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Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study.
Fang-Hua Liu,Ze Xing,Ting-Ting Gong,Jia-Yu Zhang,Yan-Hong Huang,Jing Li,Shu Liu,Yan-Ling Chen,Li-Li Li,Cheng-Zhi Jiang,Zong-Jiao Chen,Yu-Hong Zhao,Qi-Jun Wu +12 more
TL;DR: Wang et al. as discussed by the authors performed a population-based case-control study in Liaoning province to evaluate the relationship during 3 months before conception, the first trimester of pregnancy, and their single months.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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