Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Functional role of TGF-β receptors during palatal fusion in vitro
Akira Nakajima,Yoshihiro Ito,Eiji Tanaka,Remi Sano,Yoko Karasawa,Masao Maeno,Koichi Iwata,Noriyoshi Shimizu,Charles F. Shuler +8 more
TL;DR: The ability to identify and recover MEE and palatal mesenchymal cells during palatal fusion will aid in the evaluation of the different mechanistic events regulated by each TβR during palatogenesis.
Journal ArticleDOI
Association between BMP4 gene polymorphisms and cleft lip with or without cleft palate in a population from South China.
Jiansuo Hao,Ruirui Gao,Wenli Wu,Liang Hua,Yiyang Chen,Fan Li,Jiayu Liu,Dongyuan Luo,Jin Han,Hongtao Wang +9 more
TL;DR: The BMP4 gene polymorphisms rs762642, rs17563, and rs10130587 exhibit different associations with different forms of NSCL/P, suggesting that different forms in a population from South China may have different etiologies.
Journal ArticleDOI
Multidisciplinary management of a patient with van der Woude syndrome: A case report.
TL;DR: The orthodontic treatment of a girl diagnosed with VWS resulted in satisfactory outcomes and genetic testing determined a known putative splice site mutation.
Journal ArticleDOI
Operative and Immediate Postoperative Outcomes of Using a Latham-Type Dentomaxillary Appliance in Patients With Unilateral Complete Cleft Lip and Palate.
TL;DR: The use of DMA is associated with a significant reduction in the width of the cleft, and outcomes are predictable without any major adverse events or complications.
Journal ArticleDOI
Distinct Expression of miR-378 in Nonsyndromic Cleft Lip and/or Cleft Palate: A Cogitation of Skewed Sex Ratio in Prevalence.
TL;DR: The findings suggest that different expression of miR-378 is consistent with the skewed sex ratio in the prevalence of NSCL/P, revealing mechanisms for sexual dimorphism in prevalence.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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