Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
The FaceBase Consortium: a comprehensive program to facilitate craniofacial research.
Harry Hochheiser,Bruce J. Aronow,Kristin Bruk Artinger,Terri H. Beaty,James F. Brinkley,Yang Chai,David E. Clouthier,Michael L. Cunningham,Michael J. Dixon,Michael J. Dixon,Leah Rae Donahue,Scott E. Fraser,Benedikt Hallgrímsson,Junichi Iwata,Ophir D. Klein,Mary L. Marazita,Jeffrey C. Murray,Stephen A. Murray,Fernando Pardo-Manuel de Villena,John H. Postlethwait,S. Steven Potter,Linda G. Shapiro,Richard A. Spritz,Axel Visel,Axel Visel,Seth M. Weinberg,Paul A. Trainor,Paul A. Trainor +27 more
TL;DR: The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub.
Journal ArticleDOI
Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models
Kurt Reynolds,Priyanka Kumari,Lessly Sepulveda Rincon,Ran Gu,Yu Ji,Santosh Kumar,Chengji J. Zhou,Chengji J. Zhou +7 more
TL;DR: Investigation of the crosstalk between the Wnt and other signaling pathways will improve understanding of orofacial cleft development and provide opportunities for treatment and prevention.
Journal ArticleDOI
Aesthetic outcome of cleft lip and palate treatment. Perceptions of patients, families, and health professionals compared to the general public
TL;DR: Findings highlight the observed negative influence of the cleft on the patient's social activity and professional life and underline the need for the highest quality of surgical outcome for this group of patients.
Journal ArticleDOI
Understanding the human parental brain: a critical role of the orbitofrontal cortex.
TL;DR: Evidence suggesting that the orbitofrontal cortex rapidly responds to a range of infant communicative cues, such as faces and voices, supporting their efficient processing may be fundamental in supporting adults to respond rapidly and appropriately to infant needs is reviewed.
Journal ArticleDOI
Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data
Kin Y. Mok,Kin Y. Mok,UM Sheerin,Javier Simón-Sánchez,Afnan Salaka,Afnan Salaka,Lucy Chester,Valentina Escott-Price,Kiran Kumar Mantripragada,Karen M. Doherty,Alastair J. Noyce,Niccolo E. Mencacci,Steven J. Lubbe,Caroline H. Williams-Gray,Roger A. Barker,Karin van Dijk,Henk W. Berendse,Peter Heutink,Jean-Christophe Corvol,Jean-Christophe Corvol,Florence Cormier,Florence Cormier,Suzanne Lesage,Suzanne Lesage,Alexis Brice,Alexis Brice,Kathrin Brockmann,Kathrin Brockmann,Claudia Schulte,Claudia Schulte,Thomas Gasser,Thomas Gasser,Thomas Foltynie,Patricia Limousin,Karen E. Morrison,Carl E Clarke,Stephen Sawcer,Thomas T. Warner,Andrew J. Lees,Huw R. Morris,Mike A. Nalls,Andrew B. Singleton,John Hardy,Andrey Y. Abramov,Vincent Plagnol,Nigel Williams,Nicholas W. Wood +46 more
TL;DR: Clinicians should be alert to the possibility of 22q11.2 deletions in patients with Parkinson's disease who have early presentation or features associated with the chromosome 22q 11.2 deletion syndrome, or both.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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