Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Neonatal Satellite Cells Form Small Myotubes In Vitro.
P.L. Carvajal Monroy,Sander Grefte,Anne Marie Kuijpers-Jagtman,J.W. Von den Hoff,Frank A. D. T. G. Wagener +4 more
TL;DR: Age-dependent differences in stem cell properties urge careful consideration for future clinical applications in patients with cleft palate, especially in their delayed differentiation.
Journal ArticleDOI
Transforming Growth Factor Alpha Taq I Polymorphisms and Nonsyndromic Cleft Lip and/or Palate Risk: A Meta-Analysis.
TL;DR: It is indicated that the TGFA gene polymorphism might be associated with nonsyndromic CL/P susceptibility, however, these findings still need to be confirmed by single, large, well-designed prospective studies.
Journal ArticleDOI
Assessing the association between hypoxia during craniofacial development and oral clefts.
Erika Calvano Küchler,Lea Assed da Silva,Paulo Nelson-Filho,Ticiana de Medeiros Sabóia,Angela M. Rentschler,José Mauro Granjeiro,Driely Oliveira,Patricia Nivoloni Tannure,Raquel Assed Bezerra da Silva,Leonardo Santos Antunes,Michael Tsang,Alexandre R. Vieira +11 more
TL;DR: Hypoxia is involved in the oral cleft etiology, however, polymorphisms in HIF-1A are not associated with oral clefts in humans.
Journal ArticleDOI
Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach
Christl Vermeij-Keers,Anna M. Rozendaal,Antonius J.M. Luijsterburg,Benny S. Latief,Costas Lekkas,Lea Kragt,Edwin M. Ongkosuwito +6 more
TL;DR: This study showed that all CL±A including the Simonart bands can be classified, that further morphological grading of incomplete CLs is clinically relevant, and that the premaxilla forms the deficient part in alveolar deformities.
Journal ArticleDOI
Phenotypes, Developmental Basis, and Genetics of Pierre Robin Complex
Susan M. Motch Perrine,Meng Wu,Greg Holmes,Bryan C. Bjork,Ethylin Wang Jabs,Joan T. Richtsmeier +5 more
TL;DR: This review presents the current understanding of PR phenotypes, the proposed pathogenetic processes underlying them, select genes associated with PR, and available animal models that could be used to better understand the genetic basis and phenotypic variation of PR.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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