Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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A functional polymorphism in the pre-miR-146a gene is associated with the risk of nonsyndromic orofacial cleft.
Yongchu Pan,Dandan Li,Shu Lou,Chi Zhang,Yifei Du,Hongbing Jiang,Weibing Zhang,Lan Ma,Lin Wang +8 more
TL;DR: It is demonstrated that miR‐146a/rs2910164 is associated with susceptibility to NSOC, providing novel insights into the genetic etiology and underlying biology of NSOC.
Journal ArticleDOI
Developing palatal bone using human mesenchymal stem cell and stem cells from exfoliated deciduous teeth cell sheets.
Jong Min Lee,Hyun Yi Kim,Jin Sung Park,DongJoon Lee,Sushan Zhang,David W. Green,Teruo Okano,Jeong Ho Hong,Han Sung Jung +8 more
TL;DR: It is shown that osteogenic stem cell sheets have mineralization potential and might represent a new alternative to autologous bone transplantation in the reconstruction of cleft palates.
Journal ArticleDOI
Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer
Hongyi Wang,Tao Qiu,Jie Shi,Jiulong Liang,Yang Wang,Liangliang Quan,Yu Zhang,Qian Zhang,Kai Tao +8 more
TL;DR: The TP53, CDK1, SMAD3, PIK3R1 and CASP3 genes were found to be associated, not only with NSCL/P, but also with cancer.
Journal ArticleDOI
BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population
TL;DR: It is suggested that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner.
Journal ArticleDOI
Variations in WNT3 gene are associated with incidence of non-syndromic cleft lip with or without cleft palate in a northeast Chinese population.
TL;DR: The association between the WNT3 variant and NSCL/P in the population tested was confirmed and the P values for the haplotype of rs3809857-rs9890413 were observed to be statistically significant.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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