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Cleft lip and palate

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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.
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This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.

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Citations
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Cleft Palate Repair: A History of Techniques and Variations

TL;DR: A recent review as mentioned in this paper highlights the need for a global consortium on cleft care to gather expert opinions on current practices and outcomes and to standardize technique classifications, while also minimizing the occurrence of maxillary hypoplasia and palatal fistulae.
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The multidisciplinary management of fused maxillary lateral incisor with a supernumerary tooth in cleft lip adolescence.

TL;DR: The case reported in this paper presents the successful resolution of a fused maxillary lateral incisor with a supernumerary tooth, using endodontic, surgical, restorative, and orthodontics management.
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Congenital Lateral Cleft Palate of Unknown Etiology.

TL;DR: The case presented here is the third known case of laterally localized cleft palate, which is outside the natural midline cleft closure line and cause clinical complaints similar to other types of CP.
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The Online Attention to Cleft Lip and Palate Research: An Altmetric Analysis.

TL;DR: In this paper, the authors identify research articles related to cleft lip and/or cleft palate (CL/P) that generated the highest online attention and use Altmetric Explorer to identify the 100 articles.
References
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Journal ArticleDOI

Retinoic Acid Embryopathy

TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.

TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
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Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.

TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
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Transforming growth factor-β3 is required for secondary palate fusion

TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
Related Papers (5)

A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4