Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal Article
Psychological Impact of Repair Surgery in Cleft Lip and Palate
TL;DR: The current research in this area is presented, focusing on the potential impact repair surgery has on attachment, coping and resilience, along with the implications for future research.
Journal ArticleDOI
Maternal Vitamin B12 Status and Risk of Cleft Lip and Cleft Palate Birth Defects in Tamil Nadu State, India:
Ronald G. Munger,Rajarajeswari Kuppuswamy,Jyotsna Murthy,Kalpana Balakrishnan,Gurusamy Thangavel,Sankar Sambandam,Anura V Kurpad,Anne M. Molloy,Per Magne Ueland,Peter A. Mossey +9 more
TL;DR: In this paper, the causal role of maternal nutrition in orofacial clefts was investigated and it was shown that low maternal vitamin B12 and low folate status are associated with an increased risk of cleft.
Journal ArticleDOI
Excessive All-Trans Retinoic Acid Inhibits Cell Proliferation Through Upregulated MicroRNA-4680-3p in Cultured Human Palate Cells
Hiroki Yoshioka,Sai Shankar Ramakrishnan,Junbo Shim,Akiko Suzuki,Junichi Iwata,Junichi Iwata +5 more
TL;DR: In this paper, the authors show that miR-4680-3p plays a crucial role in cleft palate pathogenesis and that upregulation of miR46803p induced by all-trans retinoic acid (atRA) may cause cleft-pal palate through suppression of ERBB2 and JADE1.
Journal ArticleDOI
22q11.2 Deletion Syndrome in Colombian Patients With Syndromic Cleft Lip and/or Palate.
Suleima Carpeta,Tatiana Pineda,Maria Claudia Martínez,Gloria Osorio,Gloria Liliana Porras-Hurtado,Jorge Rojas,Ignacio Zarante,Olga Moreno-Niño +7 more
TL;DR: This study contributes with new data for genetic etiology in syndromic conditions of oral fissures in patients with cleft lip and/or cleft palate, exhibiting additional clinical findings linked to 22q11.2 deletion syndrome.
Book ChapterDOI
The Role of 2D/3D/4D Ultrasound in the Prenatal Assessment of Cleft Lip and Palate
TL;DR: The children born with defects of the hard palate have difficulties with feeding, ear infections and loss of hearing, difficulties and delay in speaking, and dental problems.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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