Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Resource utilization in primary repair of cleft palate
TL;DR: To estimate the current incidence of cleft palate in the United States and to determine national variations in resource utilization for primary repair of Cleft palate.
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Electromyographic analysis of superior orbicularis oris muscle function in children surgically treated for unilateral complete cleft lip and palate.
Liliana Szyszka-Sommerfeld,Krzysztof Woźniak,Teresa Matthews-Brzozowska,Beata Kawala,Marcin Mikulewicz +4 more
TL;DR: Patients with UCCLP have abnormal upper lip function characterized by increased activity of the superior orbicularis oris muscle during saliva swallowing and lip compression, and this may affect facial morphology.
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Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis:
T. Marzouk,I.L. Alves,Cynthia L. Wong,L. DeLucia,Christy M McKinney,C. Pendleton,B.J. Howe,Mary L. Marazita,T.K. Peter,Dorota T Kopycka-Kedzierawski,C.S. Morrison,C.S. Morrison,Hans Malmstrom,H. Wang,Erin T. Shope +14 more
TL;DR: It is suggested that individuals with orofacial clefts (OCs) are more likely to present with a range of dental anomalies than their unaffected peers.
Journal ArticleDOI
Association study between Van der Woude Syndrome causative gene GRHL3 and nonsyndromic cleft lip with or without cleft palate in a Chinese cohort.
Yirui Wang,Yimin Sun,Yongqing Huang,Yongchu Pan,Zhong-Lin Jia,Lijuan Ma,Lan Ma,Feifei Lan,Yuxi Zhou,Jiayu Shi,Xiong Yang,Lei Zhang,Hongbing Jiang,Min Jiang,Aihua Yin,Jing Cheng,Lin Wang,Yinxue Yang,Bing Shi +18 more
TL;DR: The contribution of this gene to NSCL/P etiology should be interpreted with caution based on existing evidence, and the robustness of association between GRHL3 and NSCL /P should be further validated in expanded cohorts.
Journal ArticleDOI
Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.
Nicholas J. Marini,Wei Yang,Kripa Asrani,John S. Witte,Jasper Rine,Edward J. Lammer,Gary M. Shaw +6 more
TL;DR: This comprehensive study provides further direction on candidate loci to help disentangle the folate‐related developmental phenomena in human clefting risk and revealed case‐control differences in MTRR and several other methionine cycle genes, a process implicated previously in clefted risk.
References
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Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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