Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Genetics of cleft lip and cleft palate.
TL;DR: Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or as part of Mendelian syndromes, and identification of these genes and loci has been the result of decades of research using multiple genetic approaches.
Journal ArticleDOI
A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
Struan F.A. Grant,Struan F.A. Grant,Kai Wang,Haitao Zhang,Wendy Glaberson,Kiran Annaiah,Cecilia E. Kim,Jonathan P. Bradfield,Joseph T. Glessner,Kelly A. Thomas,Maria Garris,Edward C. Frackelton,F. George Otieno,Rosetta M. Chiavacci,Hyun-Duck Nah,Richard E. Kirschner,Hakon Hakonarson,Hakon Hakonarson +17 more
TL;DR: The results strongly suggest that a locus on 8q24 is involved in the pathogenesis of NSCL/P, and this previous report acts as a de novo replication for the independent observation outlined here.
Journal ArticleDOI
Sleep and its importance in adolescence and in common adolescent somatic and psychiatric conditions.
Serge Brand,Roumen Kirov +1 more
TL;DR: It is concluded that poor or altered sleep in adolescent patients may trigger and maintain many psychiatric and physical disorders or combinations of these conditions, which presumably hinder recovery and may cross into later stages of life.
Journal ArticleDOI
Genetics of Nonsyndromic Orofacial Clefts
TL;DR: The main aim is to bring together a discussion of new and previously identified candidate genes to create a more cohesive picture of interacting pathways that shape the human craniofacial region.
Journal ArticleDOI
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.
Yanqin Yu,Xianbo Zuo,Miao He,Jinping Gao,Yuchuan Fu,Chuanqi Qin,Liuyan Meng,Wenjun Wang,Yaling Song,Yong Cheng,Fusheng Zhou,Gang Chen,Xiaodong Zheng,Xinhuan Wang,Bo Liang,Zhengwei Zhu,Xiazhou Fu,Yujun Sheng,Jiebing Hao,Zhongyin Liu,Hansong Yan,Elisabeth Mangold,Ingo Ruczinski,Jianjun Liu,Mary L. Marazita,Kerstin U. Ludwig,Terri H. Beaty,Xuejun Zhang,Liangdan Sun,Zhuan Bian +29 more
TL;DR: This study substantially increases the number of genetic susceptibility loci for NSCLP and provides important insights into the genetic aetiology of this common craniofacial malformation.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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