Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis.
TL;DR: The overall findings showed a certain association between maternal corticosteroid use and occurrence of OC, compared with non-users, but when study type was considered this association was significant only for case-control studies and not for cohort studies.
Journal ArticleDOI
From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome.
Neus Martínez-Abadías,Greg Holmes,Talia L. Pankratz,Yingli Wang,Xueyan Zhou,Ethylin Wang Jabs,Joan T. Richtsmeier +6 more
TL;DR: Palatal suture scoring and comparative 3D shape analysis from high resolution μCT images of 120 newborn mouse skulls showed that Fgfr2+/S252W mice display relatively more severe palate dysmorphologies, with contracted and more separated palatal shelves, a greater tendency to fuse the maxillary-palatine sutures and aberrant development of the inter-premaxillary suture.
Journal ArticleDOI
Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity
Heba J. Sabbagh,Nicola Innes,Bahauddin I. Sallout,Najlaa M. Alamoudi,Mustafa A. Hamdan,Nasir Al-Hamlan,Amaal I. Al-Khozami,Fatma D. Abdulhameed,Jumana Y. Al-Aama,Peter A. Mossey +9 more
TL;DR: The birth prevalence of NSOFC in Riyadh alone, and in the 3 main cities of Saudi Arabia were marginally lower than the mean global prevalence, and the CL:CLP ratio was high, and only CP was significantly associated with consanguinity.
Journal ArticleDOI
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta-analysis.
TL;DR: A systematic review and meta‐analysis of interferon regulatory factor 6 and 8q24 polymorphisms with nonsyndromic cleft lip with/without cleft palate shows robust variant effects in NSCL/P, and considering them with other genes and risk factors might be useful to improve prediction of NSCL /P occurrence.
Journal ArticleDOI
Modern Surgery-First Approach Concept in Cleft-Orthognathic Surgery: A Comparative Cohort Study with 3D Quantitative Analysis of Surgical-Occlusion Setup.
TL;DR: This study contributes to the literature by providing 3D quantitative data of the surgical-occlusion setup in surgery-first cleft-orthognathic surgery, and delivers information that may assist multidisciplinary teams to adopt the surgery- first concept to optimize cleft care.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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