Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Dynamic mRNA Expression Analysis of the Secondary Palatal Morphogenesis in Miniature Pigs.
TL;DR: A comprehensive analysis for understanding the dynamic gene regulation during palate development is provided and potential ideas and resources to further study normal palate development and the etiology of cleft palate are provided.
Journal ArticleDOI
Facial and midfacial symmetry in cleft patients: Comparison to non-cleft children and influence of the primary treatment concept
Nabil Ben Bouhjar,Johannes Kleinheinz,Dieter Dirksen,Philipp Berssenbrügge,Christoph Runte,Kai Wermker +5 more
TL;DR: An adequate treatment concept is essential to achieve better results concerning symmetry in CLAP, but symmetry values of healthy non-cleft controls are not reached.
Journal ArticleDOI
Epidemiological features of patients with nonsyndromic cleft lip and/or palate in Western Parana
Helenara Salvati Bertolossi Moreira,Renato Assis Machado,Sibele Nascimento de Aquino,Ana Lúcia Carrinho Ayrosa Rangel,Hercílio Martelli Júnior,Ricardo D. Coletta +5 more
TL;DR: The importance of identifying systemic alterations and risk factors associated with NSCL/P in the Brazilian population for planning comprehensive strategies and integrated actions for the development of preventive programs and treatment is highlighted.
Journal ArticleDOI
Descent of the human larynx: An unrecognized factor in airway distress in babies with cleft palate?
TL;DR: It is hypothesize that a cleft palate, by interrupting the sphincter function of palatopharyngeus on a high neonatal epiglottis, precipitates a need for premature and rapid maturation of the neonate's airway protection pattern, particularly during feeding, which may explain why some babies with cleft palates suffer respiratory distress during feeding.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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