Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Primary Care Approaches in Lip Palate Clefts and Prevention
TL;DR: Primary care staff, who frequently meet individuals of all age groups and sexes, should be involved in interventions aimed at reducing the risk factors that play a role in the formation of cleft lip and palate, raising awareness of the society and maintaining the care of children with lip palate clefts.
Journal ArticleDOI
Enxertos ósseos alveolares na fissura labiopalatina: protocolos atuais e perspectivas futuras
Erica Alexandra Macedo Pessoa,Andre Braune,Priscila Ladeira Casado,Patricia Nivoloni Tannure +3 more
TL;DR: A fissura labiopalatina e a malformacao congenita mais comum do ser humano, envolvendo a face e a cavidade bucal, é considerado um procedimento fundamental e quando retirado da crista iliaca do proprio paciente tem as vantagens de um material autogeno cuja incorporacao e favorecida.
Journal ArticleDOI
Genetic polymorphism of nonsyndromic cleft lip with or without cleft palate is associated with developmental dyslexia in Chinese school-aged populations
TL;DR: Association analysis with DD was performed in a Chinese population consisting 631 elementary school-aged children with 288 dyslexic cases without NSCL/P and 343 healthy controls and the T allele of rs8049367 showed significant association with DD.
Journal ArticleDOI
Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis
Huaxiang Zhao,Jieni Zhang,Mengqi Zhang,Feng Deng,Leilei Zheng,Hui Zheng,Feng Chen,Jiuxiang Lin +7 more
TL;DR: The assessment suggested there was no significant association between the MTHFD1 polymorphism rs 2236225 (c.1958G>A) and the susceptibility to NSCL/P and further investigations using a large sample size and a more advanced technique should be adopted to reach a more precise conclusion.
Journal ArticleDOI
A Combined PLS and Negative Binomial Regression Model for Inferring Association Networks from Next-Generation Sequencing Count Data
TL;DR: A new cPLS-algorithm combining partial least squares approach with negative binomial regression is suggested to reconstruct a genomic association network for high-dimensional next-generation sequencing count data, and is applicable to the raw counts data.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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