Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Chromosomal microarray analysis in the prenatal diagnosis of orofacial clefts: Experience from a single medical center in mainland China.
Han Jin,Cui Yingqiu,Liu Zequn,Huang Yanjun,Zhang Yunyan,Zhao Shufan,Chen Yiyang,Li Ru,Zhen Li,Zhang Yongling,Wang Hongtao,Liao Can +11 more
TL;DR: CMA is a valuable tool for identifying submicroscopic chromosome abnormalities in the prenatal diagnosis of oral clefts and an excellent outcome can be expected for fetuses with isolated CL that are negative for chromosomal abnormalities.
Journal ArticleDOI
Is folic acid a risk factor for oral clefts
TL;DR: A higher risk for clefts, mainly cleft lip/alveolus in the children after maternal folic acid use during early pregnancy, is reported—beyond the previous dilemma: effect or no effect of folic Acid for the prevention of oral clefts.
Journal ArticleDOI
Long-term effects of oral clefts on health care utilization: a sibling comparison
Morten Saaby Pedersen,Morten Saaby Pedersen,George L. Wehby,George L. Wehby,Dorthe Almind Pedersen,Kaare Christensen +5 more
TL;DR: It is found that children with oral clefts use more health services than their unaffected siblings in adulthood, and the effects are driven primarily by congenital malformation-related hospitalizations and intake of anti-infectives.
Journal ArticleDOI
Preferential recruitment of bone marrow-derived cells to rat palatal wounds but not to skin wounds.
TL;DR: The results indicate that bone marrow-derived cells are preferentially recruited to wounded oral mucosa but not to wounded skin, which might be related to the larger healing potential of Oral mucosa.
Journal Article
Comparison of the Pharyngeal Airway Volume between Non-Syndromic Unilateral Cleft Palate and Normal Individuals Using Cone Beam Computed Tomography.
TL;DR: 3D analysis showed that the nasal and total airway was restricted in individuals with cleft palate but the inferiorAirway was not compromised in these individuals, which would be a crucial data to be considered for surgeons during surgical planning.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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