Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Infant with Clefts Observation Outcomes Instrument (iCOO): A New Outcome for Infants and Young Children with Orofacial Clefts.
Todd C. Edwards,Carrie L. Heike,Kathleen A. Kapp-Simon,Salene M. Jones,Brian G. Leroux,Laura P. Stueckle,Claudia Crilly Bellucci,Janine Rosenberg,Meredith Albert,Cassandra L. Aspinall,Donald L. Patrick +10 more
TL;DR: In this paper, the authors evaluated the measurement properties for item and domain scores of the Infant with Clefts Observation Outcomes Instrument (iCOO) for cross-sectional (before lip surgery) and longitudi...
Journal ArticleDOI
Dexamethasone Induces Apoptosis of Embryonic Palatal Mesenchymal Cells Through the GATA-6/Bone Morphogenetic Protein-2/p38 MAPK Pathway
TL;DR: In this paper , the authors investigated the mechanism of DEX-induced cleft palate formation and showed that GATA binding protein 6 (GATA-6)/bone morphogenetic protein-2 (BMP-2) mediated apoptosis.
Journal ArticleDOI
Significance of E-cadherin Gene Mutations in Patients With Hereditary Diffuse Gastric Cancer Syndrome: A Systematic Review.
Harshit K Goud,Zainab Mehkari,Lubna Mohammed,Moiz Javed,Aldanah Althwanay,Farah Ahsan,Federico Oliveri,Ian H Rutkofsky +7 more
TL;DR: A total of 10 studies on review with different study populations showed that of the 42 patients who were diagnosed with diffuse gastric cancer, 88% of them showed a positive germline E-cadherin gene mutation and 100% of the CDH1 mutation carriers showed microscopic changes of signet ring cell adenocarcinoma of the stomach.
Journal ArticleDOI
Seasonal Influence on the Numbers of Gender-Related Orofacial Cleft Conceptions in the Netherlands.
Lisanne M van der Lek,Shariselle M. W. Pool,Kim de Jong,Christl Vermeij-Keers,Chantal M Mouës-Vink +4 more
TL;DR: In the multifactorial etiology of orofacial clefts (OFCs), environmental factors play an important role as mentioned in this paper, and to trace the influence of these factors, the timing of the cell biological mechan...
Journal ArticleDOI
Characteristics of craniofacial morphology and factors affecting them in patients with isolated cleft palate.
Kyoko Tsuji,Naoto Haruyama,Shunsuke Nomura,Naohisa Murata,Keigo Yoshizaki,Takeshi Mitsuyasu,Hiroyuki Nakano,Seiji Nakamura,Yoshihide Mori,Ichiro Takahashi +9 more
TL;DR: In this paper, the characteristics of cranio-facial morphology in patients with isolated cleft palate (ICP) and investigate the clinical factors affecting these categorised morphological characteristics.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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