Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate.
TL;DR: Investigation of association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk found NOG rs227731 genotype was associated with decreased NSCLp risk in a Northern Chinese population.
Journal ArticleDOI
Network-based identification of critical regulators as putative drivers of human cleft lip
Aimin Li,Guimin Qin,Guimin Qin,Akiko Suzuki,Mona Gajera,Junichi Iwata,Junichi Iwata,Peilin Jia,Zhongming Zhao,Zhongming Zhao +9 more
TL;DR: This work presents a global view of the CL regulatory network and a novel approach on investigating critical miRNAs, TFs and genes via combinatory regulatory networks in craniofacial development.
Journal ArticleDOI
The Role of the Wnt Signaling Pathway in Upper Jaw Development of Chick Embryo.
Tadahiro Shimomura,Masayoshi Kawakami,Kouko Tatsumi,Tatsuhide Tanaka,Shoko Morita-Takemura,Tadaaki Kirita,Akio Wanaka +6 more
TL;DR: The data suggest that the Wnt signaling pathway regulates maxillary morphogenesis and growth through Bmp4, Tbx22, Sox9, and Barx1 and might regulate N-cadherin expression via Msx1, resulting in cell aggregation for osteochondrogenesis.
Journal ArticleDOI
Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999-2008.
Anushuya Ramakrishnan,Philip J. Lupo,A. J. Agopian,Stephen H. Linder,Thomas H. Stock,Peter H. Langlois,Elena Craft +6 more
TL;DR: In this case-control study, there was no evidence that maternal exposure to environmental levels of BTEX was associated with oral clefts and the risk of oral cleft palate in offspring.
Journal ArticleDOI
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly.
TL;DR: It is demonstrated that TBX22 mutation is associated not only with cleft palate and ankyloglossia, but also cleft lip and palate and tooth agenesis, and Phenotypic variability caused by a single nucleotide substitution is clearly demonstrated.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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