Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Health professional communication and the diagnosis and care of infants born with cleft lip and palate in the U.K.
TL;DR: Analysis of the data revealed that a diagnosis of cleft lip and/or palate may not be handled sensitively by the non-specialist health professionals who are providing care.
Journal ArticleDOI
Postoperative Pain and Analgesia in Children Undergoing Palatal Surgery: A Retrospective Chart Review.
TL;DR: The results of this study indicate that frequent pain monitoring, multimodal approach, and “round‐the‐clock” analgesics may be warranted in this vulnerable patient population.
Journal ArticleDOI
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: occlusion in 8-year-olds according to the Modified Huddart and Bodenham index.
Agneta Karsten,Agneta Marcusson,Sara Rizell,Midia Najar Chalien,Arja Heliövaara,Annelise Küseler,Pål Skaare,Elin Brinck,William C. Shaw,Haydn Bellardie,Haydn Bellardie,Jeanette Mooney,Kirsten Mølsted,Paul Sæle,Phil Eyres,Gunvor Semb,Gunvor Semb +16 more
TL;DR: There was no evidence of clinically significant differences in occlusion between the two surgical methods in each trial or between the trials, and Comparisons were made with previous data in 5-year-olds.
Journal ArticleDOI
A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.
Martin Degen,Eleftheria Girousi,Julia Feldmann,Ludovica Parisi,Giorgio La Scala,Isabelle Schnyder,André Schaller,Christos Katsaros +7 more
TL;DR: Using VWS patient-derived keratinocytes, it is revealed that most of the mutated IRF6_VWS transcripts are subject to a non-sense-mediated mRNA decay mechanism, resulting in IRF 6 haploinsufficiency.
Journal ArticleDOI
Predictor(s) of Abnormal Array Comparative Genomic Hybridization Results in Patients With Cleft Lip and/or Palate.
TL;DR: This study demonstrated the diagnostic value of clinical aCGH testing in CL/P patients who present withDD/ID, dysmorphic features, other congenital anomalies, and/or family history of DD/ID.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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