Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway.
Marcella Martinelli,Ambra Girardi,Francesca Cura,Nayereh Nouri,Valentina Pinto,Francesco Carinci,Paolo Morselli,Mansoor Salehi,Luca Scapoli +8 more
TL;DR: Overall, these results indicate that NSCL/P risk factors differ among populations and confirm the importance of testing putative susceptibility variants in different genetic backgrounds.
Journal ArticleDOI
Management of Mastocytosis in Pregnancy: A Review.
Dawn Lei,Cem Akin,Anna Kovalszki +2 more
TL;DR: A case of pregnancy complicated by the need for management of indolent systemic mastocytosis is presented, as well as subtypes of mastocyTosis and management options particularly in pregnancy.
Journal ArticleDOI
Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology
TL;DR: It is found that known NSCL/P SNPs affect lip phenotypes in the general population, and an increased PRS is associated with narrow philtrum and V-shaped Cupid's bow.
Journal ArticleDOI
Cleft Palate Repair without Lateral Relaxing Incision.
TL;DR: Minimum contracture of the hard palate was useful for not only mitigating adverse maxillary growth but also for orthodontics, and the method presented was effective, with successful palatal closure and without scar formation or mucosal defects along the alveolus.
Journal ArticleDOI
Functional and aesthetic correction of secondary unilateral cleft lip nasal deformities
TL;DR: This review article presents the protocols and experience for functional and aesthetic correction of secondary unilateral cleft lip nasal deformities and a retrospective review of 219 consecutive patients treated at the Craniofacial Centre for correction ofsecondary unilateral Cleft lip nose deformities.
References
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Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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