Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Genetic variants of 20q12 contributed to non-syndromic orofacial clefts susceptibility.
X Yin,Leilei Ma,Y Li,Min Xu,W Wang,Hui-Fu Wang,Hua Yuan,Yifei Du,Sheng Li,Jingjing Ma,Hongbing Jiang,Li Wang,Wei Zhang,Yongchu Pan +13 more
TL;DR: Wang et al. as mentioned in this paper selected 24 SNPs based on a haplotype-tagging SNP strategy and evaluated their associations with risk of non-syndromic orofacial clefts in a large scale two-stage case-control study with 1,278 cases and 1,295 controls.
Journal ArticleDOI
Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis
TL;DR: The results identified an association between the GG genotype and NSCL/P risk and just confirmed this association in the Caucasian ethnicity, suggesting that theGG genotype of RFC1 (A80 G) polymorphism can be related to NSCL /P risk in some ethnicities more than others.
Journal Article
Prevalence of Congenital Heart Diseases in Patients with Orofacial Clefts: A Systematic Review.
TL;DR: CHD is commonly found in a patient with OFC and echocardiography should be used to assess CHD in patients with OFCs, according to a systematically review of prevalence rates.
Journal ArticleDOI
Environmental Risk Factors for Nonsyndromic Cleft Lip and/or Cleft Palate in Xinjiang Province, China: A Multiethnic Study:
TL;DR: The results showed that maternal pesticide exposure, paternal smoking, and antibiotic drugs use together explain nearly 60% of the variation of occurrence of NSCL/P in offspring.
Journal ArticleDOI
Holistic Communication Assessment for Young Children with Cleft Palate Using the International Classification of Functioning, Disability and Health: Children and Youth.
TL;DR: Speech-language pathologists can consider incorporating evaluation of all components and contextual factors of the ICF-CY when assessing and working with young children with CP±L to inform intervention and management practices.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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