Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
TL;DR: In this paper, the authors characterised Singapore's population-based orofacial cleft topography by ethnicity and gender, and established the cleft cohort's infant mortality rate.
Journal ArticleDOI
Association between PTCH1 and RAD54B single-nucleotide polymorphisms and non-syndromic orofacial clefts in a northern Chinese population.
Xiaotong Liu,Shaoyou Yang,Lingwei Meng,Chunyu Chen,Xiang Hui,Yuxin Jiang,Xiaohui Jiao,Kewen Lv,Tao Song +8 more
TL;DR: Investigation of the association of six single nucleotide polymorphisms (SNPs) with non‐syndromic orofacial clefts in a Northern Chinese population found one of the most common congenital malformations involves both genetic and environmental factors.
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Gene–environment interplay and MicroRNAs in cleft lip and cleft palate
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Embryology of the oral structures
Angelina Magreni,Jason G. May +1 more
TL;DR: An overview of the embryology of the oral cavity is presented and focus is placed on clinical correlation when treating children with malformations of these structures.
Journal ArticleDOI
Skeletal Maturation in Patients With Cleft Lip and/or Palate: A Systematic Review.
TL;DR: In this article, the authors evaluated the evidence regarding skeletal maturation in patients with cleft lip and/or palate (CL/P) and investigated whether the skeletal development was delayed.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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