Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Uranium concentration in umbilical cord may increase the risk for orofacial clefts.
Yingnan Guo,Lijun Liu,Wenli Ni,Yaquan Pan,Yongyan Chen,Qing Xie,Yaqiong Liu,Lei Jin,Zhiwen Li,Aiguo Ren,Linlin Wang +10 more
TL;DR: In utero exposure to high level of U was associated with increased risk of OFCs and its subtype CLP, and a dose-response relationship between the U concentration and the risk of total OFCs (P for trend = 0.009) and CLP was found.
Journal ArticleDOI
Association study of single nucleotide polymorphisms of MAFB with non-syndromic cleft lip with or without cleft palate in a population in Heilongjiang Province, northern China
TL;DR: This study investigated 3 identified single nucleotide polymorphisms in MAFB and examined them for association with NSCLP in 344 patients and 324 healthy controls in a northern Chinese Han population with a high incidence of the syndrome.
Journal ArticleDOI
Rhinoplasty for cleft and hemangioma-related nasal deformities.
TL;DR: There are several new studies that compare different rhinoplasty techniques to determine which approaches offer superior surgical outcomes; however, there needs to be a greater acceptance of objective measurements when assessing surgical results to identify a uniform surgical protocol and technique.
Journal ArticleDOI
PAX7 nucleotide variants and the risk of non-syndromic orofacial clefts in the Polish population.
Agnieszka Gaczkowska,Barbara Biedziak,Margareta Budner,Małgorzata Zadurska,Agnieszka Lasota,Kamil K. Hozyasz,Justyna Dąbrowska,Piotr Wójcicki,Anna Szponar-Żurowska,Kacper Żukowski,Paweł P. Jagodziński,Adrianna Mostowska +11 more
TL;DR: Analysis of the pooled data from the GWAS and replication study confirmed that common PAX7 nucleotide variants are significantly associated with the increased risk of nsCL/P and confirmed that PAX7 is a strong candidate gene for nsCl/P.
Journal ArticleDOI
The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery
TL;DR: The use of bioactive glasses in the repair of cleft palate malformation is discussed in this paper, where the authors highlight the particularities of alveolar defects subsequent to facial clefts, and detail the characteristics of the materials and technologies used to elaborate 3D matrices by bioprinting.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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