Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Craniofacial syndromes and sleep-related breathing disorders
TL;DR: Clinicians should have a low threshold for referral for evaluation of sleep-disordered-breathing in patients with craniofacial syndromes, and there are some distinct approaches such as nasopharyngeal airways, tongue lip adhesion, mandibular distraction osteogenesis in children with Pierre Robin sequence, and midface advancement inChildren with craniosynostoses.
Journal ArticleDOI
Oronasal fistula in cleft palate surgery
TL;DR: Oronasal fistula (ONF) is the commonest complication associated with cleft palate surgery and the main symptoms associated with ONF are nasal regurgitation of food matter and hypernasality of voice.
Journal Article
Palatoplasty: evolution and controversies.
Aik-Ming Leow,Lun-Jou Lo +1 more
TL;DR: The history of cleft palate surgery from its humble beginnings to modern-day palatoplasty is reviewed, and various pal atoplasty techniques and commonly used modifications are described.
Journal ArticleDOI
Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft.
Lulin Huang,Zhong-Lin Jia,Yi Shi,Yi Shi,Qin Du,Qin Du,Jiayu Shi,Ziyan Wang,Yandong Mou,Qingwei Wang,Qingwei Wang,Bi-He Zhang,Qing Wang,Shi Ma,He Lin,Shi-Jun Duan,Bin Yin,Yan-Song Lin,Yiru Wang,Dan Jiang,Fang Hao,Lin Zhang,Haixin Wang,Suyuan Jiang,Huijuan Xu,Cheng-wei Yang,Cheng-hao Li,Jingtao Li,Bing Shi,Zhenglin Yang,Zhenglin Yang +30 more
TL;DR: 18 genes/loci that surpassed genome-wide significance and contain developmental transcription factors (TFs) are identified, suggesting that TFs are the key factors for the pathogenesis of NSOFC subtypes.
Journal ArticleDOI
Cleft lip and palate: diagnosis and management
TL;DR: An overview ofleft lip and palate is the most common congenital facial anomaly in children that can affect appearance, speech, hearing, growth, psychosocial wellbeing and social integration.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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