Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation:
Alejandro Silva Espinosa,Julio César Martínez,Yubahhaline Molina,María Alejandra Bermúdez Gordillo,Daniel Ramos Hernández,Daniela Zárate Rivera,Blanka Pacheco Olmos,Nathaly Ramírez,Liliana Arias,Andres Zarate,Q. Diana Marcela Diaz,Andrew Collins,Álvaro Mauricio Herrera Cepeda,Ignacio Briceño Balcázar +13 more
TL;DR: In this article, the authors describe the population of patients with cleft lip and/or palate (CL/P) in terms of cleft phenotypes, gender, age, ethnic group, family history, clinical presentation (syndromic vs non...
Journal ArticleDOI
Cleft Palate Repair: A History of Techniques and Variations
TL;DR: An understanding of global protocols is crucial in an attempt to standardize technique and timing to achieve anatomical closure with optimal velopharyngeal competence, while also minimizing the occurrence of maxillary hypoplasia and palatal fistulae.
Journal Article
Association analysis of GWAS hits and non-syndromic cleft lip with/without palate with cleft alveolar in Han population of western China.
TL;DR: It is indicated that FOXE1 is the susceptible gene for cleft alveolar accompanied by NSCL/P and cleftAlveolar in Western Han Chinese population.
Journal ArticleDOI
Alkali and alkaline earth elements in maternal serum and occurrence of orofacial clefts in offspring.
Shengju Yin,Jing Wei,Chengrong Wang,Lei Jin,Linlin Wang,Zhiwen Li,Yali Zhang,Cheng-hong Yin,Aiguo Ren +8 more
TL;DR: In this article , the associations between levels of eight AEs and AEEs in maternal serum during pregnancy and occurrence of fetal orofacial clefts (OFCs) were explored.
Dissertation
Ultrasonographic Investigation of Cleft-type Compensatory Articulations
TL;DR: Investigation of cleft palate speech using ultrasound confirmed auditory-perceptual impressions and revealed covert articulatory movements, and a severity metric quantified the incremental changes in both dimensions.
References
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Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Women and smoking: a report of the Surgeon General.
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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