Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Care Barriers for Patients With Nonsyndromic Orofacial Clefts in Saudi Arabia: A Cross-Sectional Study.
TL;DR: In this article, the authors evaluated the barriers faced by patients with nonsyndromic orofacial clefts (NSOFC) throughout their treatment course in Saudi Arabia and identified three care-barrier-related factors: (1) geographic accessibility, (2) appointment availability and accessibility, and (3) scheduling-related barriers.
Journal ArticleDOI
A retrospective intercenter comparison of two surgical protocols through the dental arch relationship of 5- to 6-year-old unilateral cleft patients.
Laurent A M Thierens,Laurent A M Thierens,Arianne Lewyllie,Liesbeth Temmerman,Noëmi M C De Roo,An Verdonck,Maria Cadenas de Llano Perula,Guy Willems,Guy De Pauw,Guy De Pauw +9 more
TL;DR: The dental arch relationship of 5- to 6-year-old unilateral cleft patients treated in two Belgian cleft centers is clinically equivalent based on sagittal occlusion, despite substantial differences in their treatment protocol.
Posted ContentDOI
“mir152 hypomethylation, potentially triggered by embryonic hypoxia, as a common mechanism for non-syndromic cleft lip/palate”
Lucas Alvizi,Luciano Abreu Brito,Barbara Bischain,Camila Bassi Fernandes da Silva,Sofia Ligia Guimaraes Ramos,Gerson Shigeru Kobayashi,Jaqueline Wang,Maria Rita Passos-Bueno +7 more
TL;DR: In this paper, a reanalysis of NSCLP methylome data with genetic analysis was performed to dissect the functional effects of epigenetic changes in craniofacial malformations.
Frequency of cleft lip and palate and associated dental anomalies at islamic international dental hospital, islamabad
Omer Hafeez Kaleem,Ulfat Bashir +1 more
TL;DR: Associated dental anomalies are very common in patients with cleft lip and palate though frequency varies with the cleft type, and Maxillary deciduous canine was retained in 75% of cases.
Dissertation
Investigation of the human folate gene MTHFD1L: polymorphisms and disease risk.
TL;DR: The impact of polymorphism rs7646 on miR-197 binding suggests a mechanistic explanation of the previous association of this SNP with NTD risk and MTHFD1L expression was proven to be affected by a 24 hour exposure to cycloleucine in lymphoblast.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
Women and smoking: a report of the Surgeon General.
Journal ArticleDOI
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
TL;DR: It is suggested that Apaf1 is essential for Casp3 activation in embryonic brain and is a key regulator of developmental programmed cell death in mammals.
Journal ArticleDOI
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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