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Open AccessJournal ArticleDOI

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.

Joel Gelernter, +29 more
- 01 Sep 2019 - 
- Vol. 86, Iss: 5, pp 365-376
TLDR
The present study supports five novel alcohol-use risk loci, with particularly strong statistical support for CRHR1, which provides novel insight regarding the biology of harmful alcohol use.
About: 
This article is published in Biological Psychiatry.The article was published on 2019-09-01 and is currently open access. It has received 67 citations till now. The article focuses on the topics: Alcohol dependence & ADH1B.

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Citations
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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Hang Zhou, +36 more
- 25 May 2020 - 
TL;DR: A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts

Sandra Sanchez-Roige, +11 more
TL;DR: AUDIT scores ascertained in population-based cohorts can be used to explore the genetic basis of both alcohol consumption and alcohol use disorders.
Journal ArticleDOI

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.

Daniel F. Levey, +11 more
- 07 Jan 2020 - 
TL;DR: The authors identified novel genome-wide significant associations near genes involved with global regulation of gene expression (SATB1) and the estrogen receptor alpha (ESR1), which may have implications for genetic vulnerability across several psychiatric disorders.
Journal ArticleDOI

Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.

Sandra Sanchez-Roige, +2 more
- 01 Apr 2020 - 
TL;DR: It is demonstrated that the genetic architecture of alcohol consumption only partially overlaps with the genetics of clinically defined AUD, and how future studies will require careful phenotype harmonization to properly capture the genetic liability to AUD is outlined.
Journal ArticleDOI

Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

Kerry J. Ressler, +6 more
- 29 Mar 2022 - 
TL;DR: Ressler et al. as mentioned in this paper described the clinical features and current treatments for PTSD, examined the neurobiology of symptom domains, highlight genomic advances and discuss translational approaches to understanding mechanisms and identifying new treatments and interventions for this devastating syndrome.
References
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Journal ArticleDOI

Controlling the false discovery rate: a practical and powerful approach to multiple testing

Yoav Benjamini, +1 more
- 01 Jan 1995 - 
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI

METAL: fast and efficient meta-analysis of genomewide association scans.

Cristen J. Willer, +2 more
- 01 Sep 2010 - 
TL;DR: METAL provides a computationally efficient tool for meta-analysis of genome-wide association scans, which is a commonly used approach for improving power complex traits gene mapping studies.
Journal ArticleDOI

LD score regression distinguishes confounding from polygenicity in genome-wide association studies :

Brendan Bulik-Sullivan, +8 more
- 02 Feb 2015 - 
TL;DR: It is found that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size, and the LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control.
Journal ArticleDOI

Genetic effects on gene expression across human tissues.

Enhancing GTEx (eGTEx) groups, +10 more
- 12 Oct 2017 - 
TL;DR: It is found that local genetic variation affects gene expression levels for the majority of genes, and inter-chromosomal genetic effects for 93 genes and 112 loci are identified, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease.
Journal ArticleDOI

An atlas of genetic correlations across human diseases and traits.

Brendan Bulik-Sullivan, +20 more
- 28 Sep 2015 - 
TL;DR: This work introduces a technique—cross-trait LD Score regression—for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap, and uses this method to estimate 276 genetic correlations among 24 traits.
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