Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
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TLDR
The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.Abstract:
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.read more
Citations
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The gut microbiome: Relationships with disease and opportunities for therapy.
Juliana Durack,Susan V. Lynch +1 more
TL;DR: This review provides an overview of the influence of the Gut microbiome on host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.
Journal ArticleDOI
Administration of lactobacillus helveticus ns8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress
TL;DR: Results suggest an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis and suggest the therapeutic potential of LactobacillusNS8 in stress-related and possibly other kinds of depression.
Journal ArticleDOI
Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
Brian W. Parks,Elizabeth Nam,Elin Org,Emrah Kostem,Frode Norheim,Frode Norheim,Simon T. Hui,Calvin Pan,Mete Civelek,Christoph Rau,Brian J. Bennett,Brian J. Bennett,Margarete Mehrabian,Luke K. Ursell,Aiqing He,Lawrence W. Castellani,Bradley A. Zinker,Mark S. Kirby,Thomas A. Drake,Christian A. Drevon,Rob Knight,Rob Knight,Peter S. Gargalovic,Todd G. Kirchgessner,Eleazar Eskin,Aldons J. Lusis +25 more
TL;DR: It is shown that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provided evidence for a genetically determined set point for obesity.
Journal ArticleDOI
US Immigration Westernizes the Human Gut Microbiome.
Pajau Vangay,Abigail J. Johnson,Tonya Ward,Gabriel A. Al-Ghalith,Robin R. Shields-Cutler,Benjamin Hillmann,Sarah K. Lucas,Lalit K. Beura,Emily A. Thompson,Lisa Till,Rodolfo Batres,Bwei Paw,Shannon Pergament,Pimpanitta Saenyakul,Mary Xiong,Austin D. Kim,Grant Kim,David Masopust,Eric C. Martens,Chaisiri Angkurawaranon,Rose McGready,Purna C. Kashyap,Kathleen A. Culhane-Pera,Dan Knights +23 more
TL;DR: Using 16S and deep shotgun metagenomic DNA sequencing, it is found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions.
Journal ArticleDOI
Intestinal Microbiota Is Influenced by Gender and Body Mass Index.
Carmen Haro,Carmen Haro,Oriol A. Rangel-Zuñiga,Oriol A. Rangel-Zuñiga,Juan F. Alcala-Diaz,Juan F. Alcala-Diaz,Francisco Gomez-Delgado,Francisco Gomez-Delgado,Pablo Perez-Martinez,Pablo Perez-Martinez,Javier Delgado-Lista,Javier Delgado-Lista,Gracia M. Quintana-Navarro,Gracia M. Quintana-Navarro,Blanca B. Landa,Juan A Navas-Cortes,Manuel Tena-Sempere,Manuel Tena-Sempere,Jose C. Clemente,Jose Lopez-Miranda,Jose Lopez-Miranda,Francisco Pérez-Jiménez,Francisco Pérez-Jiménez,Antonio Camargo,Antonio Camargo +24 more
TL;DR: The results suggest that gut microbiota may differ between men and women, and that these differences may be influenced by the grade of obesity, as a function of gender and changes in body mass index.
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QIIME allows analysis of high-throughput community sequencing data.
J. Gregory Caporaso,Justin Kuczynski,Jesse Stombaugh,Kyle Bittinger,Frederic D. Bushman,Elizabeth K. Costello,Noah Fierer,Antonio Gonzalez Peña,Julia K. Goodrich,Jeffrey I. Gordon,Gavin A. Huttley,Scott T. Kelley,Dan Knights,Jeremy E. Koenig,Ruth E. Ley,Catherine A. Lozupone,Daniel McDonald,Brian D. Muegge,Meg Pirrung,Jens Reeder,Joel Sevinsky,Peter J. Turnbaugh,William A. Walters,Jeremy Widmann,Tanya Yatsunenko,Jesse R. Zaneveld,Rob Knight,Rob Knight +27 more