Matrix elasticity directs stem cell lineage specification.
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TLDR
Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.About:
This article is published in Cell.The article was published on 2006-08-25 and is currently open access. It has received 12204 citations till now. The article focuses on the topics: Mesenchymal stem cell differentiation & Stem cell fate determination.read more
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Non-toxic antifouling strategies
TL;DR: In this paper, a review of antifouling biomaterials for marine and biomedical applications is presented, focusing on the physical and chemical properties of the biomaterial to prevent the recruitment of bio-fouling organisms.
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Substrate stiffness affects early differentiation events in embryonic stem cells.
Nicholas D. Evans,Caterina Minelli,Eileen Gentleman,Vanessa L.S. LaPointe,Sameer N. Patankar,Maria Kallivretaki,Xinyong Chen,Clive J. Roberts,Molly M. Stevens +8 more
TL;DR: A fundamental role for mechanosensing in mammalian development is suggested and the mechanical environment should be taken into consideration when engineering implantable scaffolds or when producing therapeutically relevant cell populations in vitro is illustrated.
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Electrospun nanofibers for regenerative medicine.
TL;DR: This Progress Report reviews recent progress in applying electrospun nanofibers to the emerging field of regenerative medicine and highlights applications of the nanofiber‐based scaffolds in four areas of regeneratives medicine that involve nerves, dural tissues, tendons, and the tendon‐to‐bone insertion site.
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Extracellular matrix scaffolds for cartilage and bone regeneration.
Kim E M Benders,P. René van Weeren,Stephen F. Badylak,Daniel B.F. Saris,Daniel B.F. Saris,Wouter J.A. Dhert,Jos Malda +6 more
TL;DR: The rationale for using ECM-based approaches for different regenerative purposes is described and the application of ECM for cartilage or osteochondral repair is details.
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Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing.
Natalja E. Fedorovich,Jacqueline Alblas,Joost R. de Wijn,Wim E. Hennink,Ab J. Verbout,Wouter J.A. Dhert +5 more
TL;DR: This review surveys the use of hydrogels in organ printing and provides an evaluation of the recent advances in the development ofhydrogels that are promising for use in skeletal regenerative medicine.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter,Thouis R. Jones,Michael R. Lamprecht,Colin Clarke,In Han Kang,Ola Friman,David A. Guertin,Joo Han Chang,Robert A. Lindquist,Jason Moffat,Polina Golland,David M. Sabatini +11 more
TL;DR: The first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler is described, which can address a variety of biological questions quantitatively.
Journal ArticleDOI
Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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