Matrix elasticity directs stem cell lineage specification.
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TLDR
Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.About:
This article is published in Cell.The article was published on 2006-08-25 and is currently open access. It has received 12204 citations till now. The article focuses on the topics: Mesenchymal stem cell differentiation & Stem cell fate determination.read more
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Bioinspired materials for controlling stem cell fate
TL;DR: Synthetic microenvironments that aim to overcome the limitations of natural niches rather than to mimic them are reviewed, and it is anticipated that future researchers may exploit synthetic polymers to create microen environments that control stem cell behavior in clinically relevant ways.
Journal ArticleDOI
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
Britta Weigelt,Mina J. Bissell +1 more
TL;DR: It is argued that in order to get full insight into the biology of the normal and malignant breast, and to create in vivo-like models for therapeutic approaches in humans, it needs to continue to create more complex heterotypic models to approach the full context the cells encounter in the human body.
Journal ArticleDOI
Engineering the cell–material interface for controlling stem cell adhesion, migration, and differentiation
Ramses Ayala,Chao Zhang,Darren Yang,Yongsung Hwang,Aereas Aung,Sumeet S. Shroff,Fernando Teran Arce,Ratnesh Lal,Gaurav Arya,Shyni Varghese +9 more
TL;DR: The results demonstrate that the hydrophobicity of the extracellular matrix could play a considerably larger role in dictating cellular behaviors than previously anticipated and offer a platform for studying proliferation and differentiation of stem cells in a controlled manner.
Journal ArticleDOI
New materials for tissue engineering: towards greater control over the biological response
Gail Chan,David J. Mooney +1 more
TL;DR: An increased understanding of the chemical signals that direct cell differentiation, migration and proliferation, advances in scaffold design and peptide engineering that allow this signaling to be recapitulated and the development of new materials have given engineers enhanced control over the chemical properties of a material and cell fate.
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Derivation of human midbrain-specific organoids from neuroepithelial Stem Cells
Anna S. Monzel,Lisa M. Smits,Kathrin Hemmer,Siham Hachi,Edinson Lucumi Moreno,Thea van Wuellen,Javier Jarazo,Jonas Walter,Inga Brüggemann,Ibrahim Boussaad,Emanuel Berger,Ronan M. T. Fleming,Silvia Bolognin,Jens Christian Schwamborn +13 more
TL;DR: A robust human brain organoid system that is highly specific to the midbrain derived from regionally patterned neuroepithelial stem cells is described, which has the potential to be used for advanced in vitro disease modeling and therapy development.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter,Thouis R. Jones,Michael R. Lamprecht,Colin Clarke,In Han Kang,Ola Friman,David A. Guertin,Joo Han Chang,Robert A. Lindquist,Jason Moffat,Polina Golland,David M. Sabatini +11 more
TL;DR: The first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler is described, which can address a variety of biological questions quantitatively.
Journal ArticleDOI
Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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