Matrix elasticity directs stem cell lineage specification.
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TLDR
Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.About:
This article is published in Cell.The article was published on 2006-08-25 and is currently open access. It has received 12204 citations till now. The article focuses on the topics: Mesenchymal stem cell differentiation & Stem cell fate determination.read more
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Drug releasing polymer thin films: new era of surface-mediated drug delivery.
TL;DR: This review briefly summarizes the recent successes of polymer thin films, specifically those constructed by sequential polymer deposition technique, in surface-mediated drug delivery.
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Mesenchymal Stem Cell Preparations—Comparing Apples and Oranges
Wolfgang Wagner,Anthony D. Ho +1 more
TL;DR: More precise molecular and cellular markers to define subsets of MSC and to standardize the protocols for expansion of M SC are urgently needed.
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The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering:
TL;DR: The effect of ageing on extracellular matrix remodelling and its contribution to cellular functions is introduced and the current analytical technologies to study the extracllular matrix and extracecell matrix–related cellular processes are reviewed.
Journal ArticleDOI
Biomaterials Approach to Expand and Direct Differentiation of Stem Cells
TL;DR: Advances in biomaterials engineering and scaffold fabrication enable the development of ex vivo cell expansion systems to address the supply of cells and portends the alteration of stem cell fate in the absence of biological factors.
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Calcific aortic valve stenosis: methods, models, and mechanisms.
TL;DR: Key studies in humans and animals are reviewed that have shaped current paradigms in the field of CAVS, and promising future areas for research are suggested.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter,Thouis R. Jones,Michael R. Lamprecht,Colin Clarke,In Han Kang,Ola Friman,David A. Guertin,Joo Han Chang,Robert A. Lindquist,Jason Moffat,Polina Golland,David M. Sabatini +11 more
TL;DR: The first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler is described, which can address a variety of biological questions quantitatively.
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Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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