Matrix elasticity directs stem cell lineage specification.
Reads0
Chats0
TLDR
Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.About:
This article is published in Cell.The article was published on 2006-08-25 and is currently open access. It has received 12204 citations till now. The article focuses on the topics: Mesenchymal stem cell differentiation & Stem cell fate determination.read more
Citations
More filters
Journal ArticleDOI
High throughput methods applied in biomaterial development and discovery
Andrew L. Hook,Daniel G. Anderson,Robert Langer,Paul Williams,Martyn C. Davies,Morgan R. Alexander +5 more
TL;DR: The literature in this area is reviewed and it is concluded that for polymers this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip.
Journal ArticleDOI
When stem cells meet graphene: Opportunities and challenges in regenerative medicine.
TL;DR: The role and importance of stem cells in tissue engineering and regenerative medicine, the use of nanomaterials for stem cell control, the interaction between stem cells and graphene nanommaterials as well as their biocompatibility, biodistribution, and biodegradability considerations are discussed.
Journal ArticleDOI
Design and applications of man-made biomimetic fibrillar hydrogels
TL;DR: This Review discusses the assembly of peptides, block copolymer worm-like micelles and filamentous nanoparticles into fibrillar hydrogels and investigates the relationship between structure and physical as well as biochemical properties.
Journal ArticleDOI
Dynamic aspects of films prepared by a sequential deposition of species: perspectives for smart and responsive materials.
Philippe Lavalle,Jean-Claude Voegel,Jean-Claude Voegel,Dominique Vautier,Dominique Vautier,Bernard Senger,Bernard Senger,Pierre Schaaf,Vincent Ball,Vincent Ball +9 more
TL;DR: This work aims to review the most recent developments in stimuli-responsive coatings based on layer-by-layer (LBL) depositions in relationship to the properties of these coatings.
Journal ArticleDOI
Cryogels for biomedical applications
Timothy M A Henderson,Katharina Ladewig,David N. Haylock,David N. Haylock,Keith M. McLean,Andrea J. O'Connor +5 more
TL;DR: This review highlights recent advances in cryogelation techniques and starting materials that can be utilised to synthesise biocompatible and biologically relevant cryogels as well as discussing physicochemical characterisation techniques for these materials.
References
More filters
Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter,Thouis R. Jones,Michael R. Lamprecht,Colin Clarke,In Han Kang,Ola Friman,David A. Guertin,Joo Han Chang,Robert A. Lindquist,Jason Moffat,Polina Golland,David M. Sabatini +11 more
TL;DR: The first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler is described, which can address a variety of biological questions quantitatively.
Journal ArticleDOI
Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
Related Papers (5)
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more