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Open AccessJournal ArticleDOI

Metadata matters: access to image data in the real world

TLDR
An open standard format for multidimensional microscopy image data is described and it is called on the community to use open image data standards and to insist that all imaging platforms support these file formats.
Abstract
Data sharing is important in the biological sciences to prevent duplication of effort, to promote scientific integrity, and to facilitate and disseminate scientific discovery. Sharing requires centralized repositories, and submission to and utility of these resources require common data formats. This is particularly challenging for multidimensional microscopy image data, which are acquired from a variety of platforms with a myriad of proprietary file formats (PFFs). In this paper, we describe an open standard format that we have developed for microscopy image data. We call on the community to use open image data standards and to insist that all imaging platforms support these file formats. This will build the foundation for an open image data repository.

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Journal ArticleDOI

Diversity in Starvation Survival Strategies and Outcomes among Heterotrophic Proteobacteria.

TL;DR: In this paper, the authors focus on carbon starvation as a growth-arresting condition that limits availability not only of substrates for biosynthesis but also of energy for ongoing maintenance of the electrochemical gradient across the cell envelope and cellular integrity.
Journal ArticleDOI

Serotonin Signals Overcome Loser Mentality in Drosophila.

TL;DR: It is reported that elevated serotonin (5-HT) signaling helps a loser to overcome suppressive neurological states and demonstrate an ancient neural mechanism of regulating depressive behavioral states after distressing events.
Journal ArticleDOI

Personalized Oncology Suite: integrating next-generation sequencing data and whole-slide bioimages.

TL;DR: A bioinformatics platform – Personalized Oncology Suite (POS) – that integrates clinical data, NGS data and whole-slide bioimages from tissue sections and provides different visualization techniques and offers sophisticated upload and download possibilities.
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Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned

TL;DR: The essential elements of assembling an integromics framework from a more detailed perspective are explored and it is stressed thatIntegromics is not just a set of tools, but rather a cohesive paradigm for how modern bioinformatics can be enhanced.
Journal ArticleDOI

GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images

TL;DR: GoIFISH is a widely applicable, user-friendly system tailored for the objective and semi-automated visualization, detection and quantification of genomic alterations and protein expression obtained from fluorescence in situ analysis.
References
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Journal ArticleDOI

Genome-wide atlas of gene expression in the adult mouse brain

Ed S. Lein, +109 more
- 11 Jan 2007 - 
TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal ArticleDOI

Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function

TL;DR: A high-resolution fluorescent in situ hybridization procedure was developed and employed to comprehensively evaluate mRNA localization dynamics during early Drosophila embryogenesis, indicating major roles for mRNA localization in nucleating localized cellular machineries.
Journal ArticleDOI

The Zebrafish Information Network: the zebrafish model organism database

TL;DR: The Zebrafish Information Network (ZFIN) provides an integrated representation of mutants, genes, genetic markers, mapping panels, publications and community resources such as meeting announcements and contact information.
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