Journal ArticleDOI
Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model.
TLDR
FKBP5 presents the possibility to better understand the molecular and cellular factors contributing to a disease-relevant gene by environment interaction, with implications for the development of biomarkers and interventions for psychiatric disorders.About:
This article is published in Biological Psychiatry.The article was published on 2018-05-15. It has received 143 citations till now.read more
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Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms.
TL;DR: Elucidating the role of epigenetic mechanisms in intergenerational effects through prospective, multi‐generational studies may ultimately yield a cogent understanding of how individual, cultural and societal experiences permeate the authors' biology.
Journal ArticleDOI
Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
TL;DR: A BDNF stress–sensitivity hypothesis is proposed, which posits that disruption of endogenous BDNF activity by common factors potentiates sensitivity to stress and, by extension, vulnerability to stress-inducible illnesses.
Journal ArticleDOI
Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope?
TL;DR: This review will cover tests detecting altered HPA axis function and the specific treatment options such as glucocorticoid receptor (GR) antagonists, corticotropin-releasing hormone 1 (CRH1) receptor antagonists, tryptophan 2,3-dioxygenase (TDO) inhibitors and FK506 binding protein 5 (FKBP5) receptors antagonists.
Journal ArticleDOI
Substance P and pain chronicity.
TL;DR: This review focuses on functional neuronal plasticity in spinal dorsal horn neurons as a major relay for nociceptive information in spinal and brainstem second-order neurons.
Journal ArticleDOI
Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.
TL;DR: A platform on which the field of ACE-induced phenotypes in mental health may build is provided, with suggestions for advances using new technologies and novel research directions.
References
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Genome-wide atlas of gene expression in the adult mouse brain
Ed S. Lein,Michael Hawrylycz,Nancy Ao,Mikael Ayres,Amy Bensinger,Amy Bernard,Andrew F. Boe,Mark S. Boguski,Mark S. Boguski,Kevin S. Brockway,Emi J. Byrnes,Lin Chen,Li Chen,Tsuey-Ming Chen,Mei Chi Chin,Jimmy Chong,Brian E. Crook,Aneta Czaplinska,Chinh Dang,Suvro Datta,Nick Dee,Aimee L. Desaki,Tsega Desta,Ellen Diep,Tim A. Dolbeare,Matthew J. Donelan,Hong-Wei Dong,Jennifer G. Dougherty,Ben J. Duncan,Amanda Ebbert,Gregor Eichele,Lili K. Estin,Casey Faber,Benjamin A.C. Facer,Rick Fields,Shanna R. Fischer,Tim P. Fliss,Cliff Frensley,Sabrina N. Gates,Katie J. Glattfelder,Kevin R. Halverson,Matthew R. Hart,John G. Hohmann,Maureen P. Howell,Darren P. Jeung,Rebecca A. Johnson,Patrick T. Karr,Reena Kawal,Jolene Kidney,Rachel H. Knapik,Chihchau L. Kuan,James H. Lake,Annabel R. Laramee,Kirk D. Larsen,Christopher Lau,Tracy Lemon,Agnes J. Liang,Ying Liu,Lon T. Luong,Jesse Michaels,Judith J. Morgan,Rebecca J. Morgan,Marty Mortrud,Nerick Mosqueda,Lydia Ng,Randy Ng,Geralyn J. Orta,Caroline C. Overly,Tu H. Pak,Sheana Parry,Sayan Dev Pathak,Owen C. Pearson,Ralph B. Puchalski,Zackery L. Riley,Hannah R. Rockett,Stephen A. Rowland,Joshua J. Royall,Marcos J. Ruiz,Nadia R. Sarno,Katherine Schaffnit,Nadiya V. Shapovalova,Taz Sivisay,Clifford R. Slaughterbeck,Simon Smith,Kimberly A. Smith,Bryan I. Smith,Andy J. Sodt,Nick N. Stewart,Kenda-Ruth Stumpf,Susan M. Sunkin,Madhavi Sutram,Angelene Tam,Carey D. Teemer,Christina Thaller,Carol L. Thompson,Lee R. Varnam,Axel Visel,Axel Visel,Ray M. Whitlock,Paul Wohnoutka,Crissa K. Wolkey,Victoria Y. Wong,Matthew J.A. Wood,Murat B. Yaylaoglu,Rob Young,Brian L. Youngstrom,Xu Feng Yuan,Bin Zhang,Theresa A. Zwingman,Allan R. Jones +109 more
TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal ArticleDOI
Stress and the brain: from adaptation to disease
TL;DR: In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.
Journal ArticleDOI
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Jordan W. Smoller,Kenneth S. Kendler,Nicholas John Craddock,Phil Lee,Benjamin M. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Patrick F. Sullivan,Shaun Purcell,Richard Anney,Jan K. Buitelaar,Ayman H. Fanous,Stephen V. Faraone,Witte J.G. Hoogendijk,Klaus-Peter Lesch,Douglas F. Levinson,Roy H. Perlis,Marcella Rietschel,Brien P. Riley,Edmund J.S. Sonuga-Barke,Russell Schachar,Thomas G. Schulze,Anita Thapar,Michael C. Neale,Patrick Bender,Sven Cichon,Mark J. Daly,John R. Kelsoe,Thomas Lehner,Michael Conlon O'Donovan,Pablo V. Gejman,Jonathan Sebat,Pamela Sklar +33 more
TL;DR: The findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset, and variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology.
Journal ArticleDOI
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S. Hong Lee,Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Stephen V. Faraone,Shaun Purcell,Shaun Purcell,Shaun Purcell,Roy H. Perlis,Roy H. Perlis,Bryan J. Mowry,Bryan J. Mowry,Anita Thapar,Michael E. Goddard,John S. Witte,Devin Absher,Ingrid Agartz,Huda Akil,Farooq Amin,Ole A. Andreassen,Adebayo Anjorin,Richard Anney,Verneri Anttila,Dan E. Arking,Philip Asherson,Maria Helena Pinto de Azevedo,Lena Backlund,Judith A. Badner,Anthony J. Bailey,Tobias Banaschewski,Jack D. Barchas,Michael R. Barnes,Thomas B. Barrett,Nicholas Bass,Agatino Battaglia,Michael Bauer,Mònica Bayés,Frank Bellivier,Sarah E. Bergen,Sarah E. Bergen,Sarah E. Bergen,Wade H. Berrettini,Catalina Betancur,Catalina Betancur,Catalina Betancur,Thomas Bettecken,Joseph Biederman,Elisabeth B. Binder,Donald W. Black,Douglas Blackwood,Cinnamon S. Bloss,Michael Boehnke,Dorret I. Boomsma,Gerome Breen,Gerome Breen,René Breuer,Richard Bruggeman,Paul Cormican,Nancy G. Buccola,Jan K. Buitelaar,William E. Bunney,Joseph D. Buxbaum,William Byerley,Enda M. Byrne,Sian Caesar,Wiepke Cahn,Rita M. Cantor,Miguel Casas,Aravinda Chakravarti,Kimberly Chambert,Khalid Choudhury,Sven Cichon,Sven Cichon,C. Robert Cloninger,David A. Collier,Edwin H. Cook,Hilary Coon,Bru Cormand,Aiden Corvin,William Coryell,David Craig,Ian W. Craig,Jennifer Crosbie,Michael L. Cuccaro,David Curtis,Darina Czamara,Susmita Datta,Geraldine Dawson,Richard O. Day,Eco J. C. de Geus,Franziska Degenhardt,Srdjan Djurovic,Gary Donohoe,Alysa E. Doyle,Jubao Duan,Frank Dudbridge,Eftichia Duketis,Richard P. Ebstein,Howard J. Edenberg,Josephine Elia,Sean Ennis,Bruno Etain,Ayman H. Fanous,Ayman H. Fanous,Anne Farmer,I. Nicol Ferrier,Matthew Flickinger,Eric Fombonne,Tatiana Foroud,Josef Frank,Barbara Franke,Christine Fraser,Robert Freedman,Nelson B. Freimer,Christine M. Freitag,Marion Friedl,Louise Frisén,Louise Gallagher,Pablo V. Gejman,Lyudmila Georgieva,Elliot S. Gershon,Daniel H. Geschwind,Ina Giegling,Michael Gill,Scott D. Gordon,Katherine Gordon-Smith,Katherine Gordon-Smith,Elaine K. Green,Tiffany A. Greenwood,Dorothy E. Grice,Magdalena Gross,Detelina Grozeva,Weihua Guan,Weihua Guan,Hugh Gurling,Lieuwe de Haan,Jonathan L. Haines,Hakon Hakonarson,Joachim Hallmayer,Steven P. Hamilton,Marian L. Hamshere,Thomas Hansen,Annette M. Hartmann,Martin Hautzinger,Andrew C. Heath,Anjali K. Henders,Stefan Herms,Stefan Herms,Ian B. Hickie,Maria Hipolito,Susanne Hoefels,Peter Holmans,Florian Holsboer,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Christina M. Hultman,Vanessa Hus,Andres Ingason,Marcus Ising,Stéphane Jamain,Edward G. Jones,Ian Jones,Lisa Jones,Jung-Ying Tzeng,Anna K. Kähler,René S. Kahn,Radhika Kandaswamy,Matthew C. Keller,James L. Kennedy,Elaine Kenny,Lindsey Kent,Yunjung Kim,George Kirov,Sabine M. Klauck,Lambertus Klei,James A. Knowles,Martin A. Kohli,Daniel L. Koller,Bettina Konte,Ania Korszun,Lydia Krabbendam,Robert Krasucki,Jonna Kuntsi,Phoenix Kwan,Mikael Landén,Mikael Landén,Niklas Långström,Mark Lathrop,Jacob Lawrence,William Lawson,Marion Leboyer,David H. Ledbetter,Phil Lee,Todd Lencz,Todd Lencz,Klaus-Peter Lesch,Klaus-Peter Lesch,Douglas F. Levinson,Cathryn M. Lewis,Jun Li,Paul Lichtenstein,Jeffrey A. Lieberman,Danyu Lin,Don H. Linszen,Chunyu Liu,Falk W. Lohoff,Sandra K. Loo,Catherine Lord,Jennifer K. Lowe,Susanne Lucae,Donald J. MacIntyre,Pamela A. F. Madden,Elena Maestrini,Patrik K. E. Magnusson,Pamela B. Mahon,Wolfgang Maier,Anil K. Malhotra,Anil K. Malhotra,Shrikant Mane,Christa Lese Martin,Nicholas G. Martin,Manuel Mattheisen,Manuel Mattheisen,Keith Matthews,Morten Mattingsdal,Steven A. McCarroll,Kevin A. McGhee,James J. McGough,Patrick J. McGrath,Peter McGuffin,Melvin G. McInnis,Andrew M. McIntosh,Rebecca McKinney,Alan W. McLean,Francis J. McMahon,William M. McMahon,Andrew McQuillin,Helena Medeiros,Sarah E. Medland,Sandra Meier,Ingrid Melle,Fan Meng,Jobst Meyer,Christel M. Middeldorp,Lefkos T. Middleton,Vihra Milanova,Ana Miranda,Anthony P. Monaco,Anthony P. Monaco,Grant W. Montgomery,Jennifer L. Moran,Daniel Moreno-De-Luca,Gunnar Morken,Derek W. Morris,Eric M. Morrow,Valentina Moskvina,Pierandrea Muglia,Thomas W. Mühleisen,Walter J. Muir,Bertram Müller-Myhsok,Michael T. Murtha,Richard M. Myers,Inez Myin-Germeys,Michael C. Neale,Stan F. Nelson,Caroline M. Nievergelt,Ivan Nikolov,Vishwajit L. Nimgaonkar,Willem A. Nolen,Markus M. Nöthen,John I. Nurnberger,Evaristus A. Nwulia,Dale R. Nyholt,Colm O'Dushlaine,Robert D. Oades,Ann Olincy,Guiomar Oliveira,Line Olsen,Roel A. Ophoff,Roel A. Ophoff,Urban Ösby,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Andrew D. Paterson,Carlos N. Pato,Michele T. Pato,Brenda W.J.H. Penninx,Michele L. Pergadia,Margaret A. Pericak-Vance,Benjamin S. Pickard,Jonathan Pimm,Joseph Piven,Danielle Posthuma,Danielle Posthuma,James B. Potash,Fritz Poustka,Peter Propping,Vinay Puri,Digby Quested,Emma M. Quinn,Josep Antoni Ramos-Quiroga,Henrik B. Rasmussen,Soumya Raychaudhuri,Soumya Raychaudhuri,Karola Rehnström,Andreas Reif,Marta Ribasés,John P. Rice,Marcella Rietschel,Kathryn Roeder,Herbert Roeyers,Lizzy Rossin,Aribert Rothenberger,Guy A. Rouleau,Douglas M. Ruderfer,Dan Rujescu,Alan R. Sanders,Stephen Sanders,Susan L. Santangelo,Susan L. Santangelo,Joseph A. Sergeant,Russell Schachar,Martin Schalling,Alan F. Schatzberg,William A. Scheftner,Gerard D. Schellenberg,Stephen W. Scherer,Nicholas J. Schork,Thomas G. Schulze,Thomas G. Schulze,Johannes Schumacher,Markus J. Schwarz,Edward M. Scolnick,Laura J. Scott,Jianxin Shi,Paul D. Shilling,Stanley I. Shyn,Jeremy M. Silverman,Susan L. Slager,Susan L. Smalley,Johannes H. Smit,Erin N. Smith,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,David St Clair,Matthew W. State,Michael Steffens,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,John Strauss,Jana Strohmaier,T. Scott Stroup,James S. Sutcliffe,Peter Szatmari,Szabocls Szelinger,Srinivasa Thirumalai,Robert C. Thompson,Alexandre A. Todorov,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Jim van Os,Astrid M. Vicente,Astrid M. Vicente,Astrid M. Vicente,Veronica J. Vieland,John B. Vincent,Peter M. Visscher,Christopher A. Walsh,Thomas H. Wassink,Stanley J. Watson,Myrna M. Weissman,Thomas Werge,Thomas F. Wienker,Ellen M. Wijsman,Gonneke Willemsen,Nigel Williams,A. Jeremy Willsey,Stephanie H. Witt,Wei Xu,Allan H. Young,Allan H. Young,Timothy W. Yu,Stanley Zammit,Peter P. Zandi,Peng Zhang,Frans G. Zitman,Sebastian Zöllner,Bernie Devlin,John R. Kelsoe,John R. Kelsoe,Pamela Sklar,Mark J. Daly,Mark J. Daly,Michael Conlon O'Donovan,Nicholas John Craddock,Patrick F. Sullivan,Jordan W. Smoller,Jordan W. Smoller,Kenneth S. Kendler,Naomi R. Wray +405 more
TL;DR: Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Journal ArticleDOI
A subcellular map of the human proteome
Peter Thul,Lovisa Åkesson,Mikaela Wiking,Diana Mahdessian,Aikaterini Geladaki,Hammou Ait Blal,Tove Alm,Anna Asplund,Lars Björk,Lisa M. Breckels,Anna Bäckström,Frida Danielsson,Linn Fagerberg,Jenny Fall,Laurent Gatto,Christian Gnann,Sophia Hober,Martin Hjelmare,Fredric Johansson,Sunjae Lee,Cecilia Lindskog,Jan Mulder,Claire M. Mulvey,Peter Nilsson,Per Oksvold,Johan Rockberg,Rutger Schutten,Jochen M. Schwenk,Åsa Sivertsson,Evelina Sjöstedt,Marie Skogs,Charlotte Stadler,Devin P. Sullivan,Hanna Tegel,Casper F. Winsnes,Cheng Zhang,Martin Zwahlen,Adil Mardinoglu,Fredrik Pontén,Kalle von Feilitzen,Kathryn S. Lilley,Mathias Uhlén,Emma Lundberg +42 more
TL;DR: A subcellular map of the human proteome is presented to facilitate functional exploration of individual proteins and their role in human biology and disease and integrated into existing network models of protein-protein interactions for increased accuracy.
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