R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
More filters
Journal ArticleDOI
Repeated sequence DNA comparisons between Triticum and Aegilops species
TL;DR: The results are consistent with the hypothesis that speciation is accompanied by quantitative changes in the repeated sequence complements of genomes, and using a DNA probe from Aegilops speltoides that contains the most highly repeated sequences, diploid Aegilop species could be distinguished from diploids Triticum species.
Journal ArticleDOI
The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3.
Georg Widera,Richard A. Flavell +1 more
TL;DR: Comparison of the DNA sequence of the exon encoding the beta 2 domain of psi A beta 3 in the b or k haplotypes with functional class II genes shows that a deletion of eight nucleotides has occurred, such that the psi Abeta 3 sequence cannot be translated into afunctional class II protein, which suggests that psi A Beta 3 is a pseudogene.
Journal ArticleDOI
Structure of the human G gamma-A gamma-delta-beta-globin gene locus
TL;DR: A physical map of the human G gamma-, A gamma-, delta-, and beta-globin genes is constructed, which spans more than 40 kilobases and shows the following intergene distances.
Journal ArticleDOI
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.
D H Sherman,P S Hochman,R Dick,R Tizard,K L Ramachandran,Richard A. Flavell,Brigitte T. Huber +6 more
TL;DR: Molecular analysis of the heterodimeric T- cell antigen receptor of insulin-specific class II-restricted T-cell hybridomas derived from C57BL/6 (B6) wild-type and B6.C-H-2bm12 (bm12) mutant mice revealed that such T cells use a diverse V gene repertoire.
Journal ArticleDOI
Preferential Th1 immune response in invariant chain-deficient mice.
TL;DR: It is suggested that defective Ag presentation in Ii−/− mice leads selectively to a Th1 effector response.