R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
B Cells Suppress the Inflammatory Response in a Mouse Model of Primary Biliary Cirrhosis
Yuki Moritoki,Yuki Moritoki,Weici Zhang,Koichi Tsuneyama,Katsunori Yoshida,Kanji Wakabayashi,Guo-Xiang Yang,Christopher L. Bowlus,William M. Ridgway,Yoshiyuki Ueno,Aftab A. Ansari,Ross L. Coppel,Ian R. Mackay,Richard A. Flavell,M. Eric Gershwin,Zhe-Xiong Lian +15 more
TL;DR: B cells have a suppressive effect on the inflammatory response in the dnTGF-betaRII model of primary biliary cirrhosis, and are associated with decreased amounts of liver inflammation and bile duct damage.
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CIITA activates the expression of MHC class II genes in mouse T cells.
Cheong-Hee Chang,Soon-Cheol Hong,Christopher C.W. Hughes,Charles A. Janeway,Richard A. Flavell +4 more
TL;DR: It is shown that human T cells expressing MHC class II have CIITA transcripts while MHCclass II-negative human T Cells and mouse T cells do not and these data indicate that the expression of CI ITA explains the expression or lack of expression of M HC class II in human and mouseT cells respectively.
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Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses
Jun Siong Low,Yagmur Farsakoglu,Maria Carolina Amezcua Vesely,Maria Carolina Amezcua Vesely,Esen Sefik,Joseph B. Kelly,Christian C. D. Harman,Ruaidhri Jackson,Justin A. Shyer,Xiaodong Jiang,Linda S. Cauley,Richard A. Flavell,Richard A. Flavell,Susan M. Kaech,Susan M. Kaech +14 more
TL;DR: It is found that memory T cells in the different anatomical locations have unique reactivation mechanics in terms of reactivation kinetics and efficiency, as well as antigen-presenting cell requirements that drive qualitatively distinct recall responses.
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The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-b7-1 (nod-rip-b7-1) mice
TL;DR: It is shown that both CD4 and CD8 T cells were necessary for the accelerated onset of diabetes, but that B cells, which are needed for diabetes to occur in normal NOD mice, are not required.
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Emerging Roles of L-Type Voltage-Gated and Other Calcium Channels in T Lymphocytes
TL;DR: This paper focuses mainly on the role of the Cav1 channels found expressed by T lymphocytes, where these channels appear to operate in a T cell receptor stimulation-dependent and voltage sensor independent manner.