R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis
Dengke K. Ma,Mi Hyeon Jang,Junjie U. Guo,Yasuji Kitabatake,Min Lin Chang,Nattapol Pow-anpongkul,Richard A. Flavell,Binfeng Lu,Guo Li Ming,Hongjun Song +9 more
TL;DR: Mechanistically, Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes critical for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor.
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Toll-like receptor 3 promotes cross-priming to virus-infected cells
Oliver Schulz,Sandra S. Diebold,Margaret Chen,Tanja I. Näslund,Martijn A. Nolte,Lena Alexopoulou,Lena Alexopoulou,Yasu-Taka Azuma,Richard A. Flavell,Peter Liljeström,Caetano Reis e Sousa +10 more
TL;DR: It is shown that murine CD8α+ dendritic cells are activated by double-stranded (ds)RNA present in virally infected cells but absent from uninfected cells, which indicates that TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not directly infect dendedritic cells.
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Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1
Fayyaz S. Sutterwala,Yasunori Ogura,Marian Szczepanik,Marian Szczepanik,Maria Lara-Tejero,G. Scott Lichtenberger,Ethan P. Grant,John Bertin,Anthony J. Coyle,Jorge E. Galán,Philip W. Askenase,Richard A. Flavell +11 more
TL;DR: It is shown that ASC- and NALP3-deficient mice also demonstrate an impaired contact hypersensitivity response to the hapten trinitrophenylchloride, suggesting that NALp3 plays a specific role in the caspase-1 activation pathway.
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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi,Naohiro Inohara,Lorraine D. Hernandez,Jorge E. Galán,Gabriel Núñez,Charles A. Janeway,Ruslan Medzhitov,Richard A. Flavell +7 more
TL;DR: Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems.
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Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
TL;DR: It is demonstrated that Jagged constitutes an instructive signal for Th2 differentiation, which is independent of IL4/STAT6, and induced by APC is abrogated in T cells lacking the Notch effector RBPJkappa.