R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils
Etsushi Kuroda,Victor W. Ho,Jens Ruschmann,Frann Antignano,Melisa J. Hamilton,Michael J. Rauh,Andrey Antov,Richard A. Flavell,Laura M. Sly,Gerald Krystal +9 more
TL;DR: It is shown that IL-3 and, to a lesser extent, GM-CSF skew murine Mφ progenitors toward an M2 phenotype, especially in the absence of SHIP, and that SHIP represses M2 skewing not by preventing skewing within M φs themselves but by inhibiting IL-4 production from basophils.
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A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease
Penelope Pelczar,Mario Witkowski,Laura Garcia Perez,Jan Kempski,Anna G. Hammel,Leonie Brockmann,Dörte Kleinschmidt,Sandra Wende,Cathleen Haueis,Tanja Bedke,Marco Witkowski,Susanne Krasemann,Stefan Steurer,Carmen J. Booth,Philipp Busch,Alexandra König,Ursula Rauch,Daniel Benten,Jakob R. Izbicki,Thomas Rösch,Ansgar W. Lohse,Till Strowig,Nicola Gagliani,Richard A. Flavell,Samuel Huber +24 more
TL;DR: It is reported that CD4+ T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22, which suggests that anti–TNF-α therapy may act at least in part by suppressing IL- 22BP and point toward a more specific potential therapy for IBD.
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Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation
Xiu Lian Sun,Yili Wu,Bin Chen,Zhuohua Zhang,Wei Hui Zhou,Yigang Tong,Jun Ying Yuan,Kun Xia,Hinrich Gronemeyer,Richard A. Flavell,Weihong Song +10 more
TL;DR: This study provides a novel mechanism by which RCAN1 functions as a mediator of stress- and Aβ-induced neuronal death, and overexpression ofRCAN1 due to an extra copy of the RCAN 1 gene on chromosome 21 contributes to AD pathogenesis in DS.
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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
TL;DR: The data unequivocally identify c-Cbl as a novel negative regulator of developmental and functional properties of HSCs and its role in HSC development and functions is identified.
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The Ro Autoantigen Binds Misfolded U2 Small Nuclear RNAs and Assists Mammalian Cell Survival after UV Irradiation
TL;DR: It is proposed that Ro plays a general role in small RNA quality control and that this function is important for cell survival after ultraviolet irradiation.