R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Saquib A. Lakhani,Ali Masud,Keisuke Kuida,George A. Porter,Carmen J. Booth,Wajahat Z. Mehal,Irteza Inayat,Richard A. Flavell +7 more
TL;DR: It is concluded that caspases 3 and 7 are critical mediators of mitochondrial events of apoptosis, and both are highly resistant to both mitochondrial and death receptor–mediated apoptosis.
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TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
Felix Yarovinsky,Dekai Zhang,John F. Andersen,Gerard Bannenberg,Charles N. Serhan,Matthew S. Hayden,Sara Hieny,Fayyaz S. Sutterwala,Richard A. Flavell,Sankar Ghosh,Alan Sher +10 more
TL;DR: A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.
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A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
Dekai Zhang,Guolong Zhang,Matthew S. Hayden,Matthew B. Greenblatt,Crystal Bussey,Richard A. Flavell,Sankar Ghosh +6 more
TL;DR: A member of the mammalian TLR family, TLR11, is reported that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells, indicating a potentially important role in preventing infection of internal organs of the urogenital system.
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Natural regulatory T cells control the development of atherosclerosis in mice.
Hafid Ait-Oufella,Benoît L. Salomon,Stephane Potteaux,Anna-Karin L. Robertson,Pierre Gourdy,Joffrey Zoll,Régine Merval,Bruno Esposito,José L. Cohen,Sylvain Fisson,Richard A. Flavell,Göran K. Hansson,David Klatzmann,Alain Tedgui,Ziad Mallat +14 more
TL;DR: It is shown that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models.
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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
Koichi Tabeta,Philippe Georgel,Edith M. Janssen,Xin Du,Kasper Hoebe,Karine Crozat,Suzanne Mudd,Louis Shamel,Sosathya Sovath,Jason Goode,Lena Alexopoulou,Richard A. Flavell,Bruce Beutler +12 more
TL;DR: The phenotypic effect of the Tlr9(CpG1) allele points to a critical role for TLR9 in viral sensing and identifies a vulnerable amino acid within the ectodomain of three TLR proteins, essential for a ligand response.