R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Gadd45β and Gadd45γ are critical for regulating autoimmunity
TL;DR: The Gadd45β/Gadd45γ-mediated control of effector autoimmune lymphocytes as an attractive novel target for autoimmune disease therapy is identified.
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Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation
Adrian J. Błażejewski,Sophie Thiemann,Alexander Schenk,Marina C. Pils,Eric J. C. Gálvez,Urmi Roy,Ulrike Heise,Marcel R. de Zoete,Marcel R. de Zoete,Richard A. Flavell,Richard A. Flavell,Till Strowig +11 more
TL;DR: Data show that canonical inflammasome activation controls caspase-1 activity, contributing to exacerbation of chemical-induced colitis.
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IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury
Megan N. Ballinger,Michael W. Newstead,Xianying Zeng,Urvashi Bhan,Xiaokui M. Mo,Steven L. Kunkel,Bethany B. Moore,Richard A. Flavell,John W. Christman,Theodore J. Standiford +9 more
TL;DR: In this article, the contribution of macrophages in pulmonary fibrosis was assessed and it was shown that IL-1R-associated kinase-M (IRAK-M) is a MyD88-dependent inhibitor of TLR signaling, which suppresses deleterious inflammation but may paradoxically promote fibrogenesis.
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Detection of differentially abundant cell subpopulations in scRNA-seq data.
Jun Zhao,Ariel Jaffe,Henry Li,Ofir Lindenbaum,Esen Sefik,Ruaidhri Jackson,Xiuyuan Cheng,Richard A. Flavell,Yuval Kluger +8 more
TL;DR: DA-seq as mentioned in this paper is a targeted approach for identifying differentially abundant subpopulations not restricted to clusters, which quantifies a local DA measure for each cell, which is computed from its k nearest neighboring cells across a range of k values.
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Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut
Louis A. Magnarelli,Jacob W. IJdo,John F. Anderson,Steven J. Padula,Richard A. Flavell,Erol Fikrig +5 more
TL;DR: Indirect fluorescent-antibody staining methods with Ehrlichia equi (MRK or BDS strains) and Western blot analyses containing a human granulocytic ehrlichiosis (HGE) agent (NCH-1 strain) were used to confirm probable human cases of infection in Connecticut during 1995 and 1996.