R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
Masako Miura,Xiao Dong Chen,Matthew R. Allen,Yanming Bi,Stan Gronthos,Byoung Moo Seo,Saquib A. Lakhani,Richard A. Flavell,Xin-Hua Feng,Pamela Gehron Robey,M. F. Young,Songtao Shi +11 more
TL;DR: It is demonstrated that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-β/Smad2 pathway and cell cycle progression and caused accelerated bone loss in ovariectomized mice.
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Isolation of β-globin related genes from a human cosmid library.
TL;DR: A human gene library was constructed using an improved cloning technique for cosmid vectors using the human beta-globin related genes and encompassing approx.
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Regulation of the Th2 cytokine locus by a locus control region.
TL;DR: Investigation of the global locus-specific regulation of these genes using BAC transgenic mice containing the murine Th2 cytokine cluster carrying an IL4 promoter-luciferase reporter suggested the presence of an LCR in the locus.
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Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection
Natalya V. Serbina,William A. Kuziel,Richard A. Flavell,Shizuo Akira,Barrett J. Rollins,Eric G. Pamer +5 more
TL;DR: The results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions.
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