R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
More filters
Journal ArticleDOI
YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
Soo Seok Hwang,Sung Woong Jang,Minkyung Kim,Lark Kyun Kim,Bong Sung Kim,Hyeong Su Kim,Kiwan Kim,Wonyong Lee,Richard A. Flavell,Richard A. Flavell,Gap Ryol Lee +10 more
TL;DR: It is shown that YY1 expression is lower in Treg cells than Tconv cells, and its overexpression causes a marked reduction of Foxp3 expression and abrogation of suppressive function of T Reg cells.
Journal ArticleDOI
ICOS Mediates the Development of Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice
TL;DR: It is concluded that ICOS is critically important for the induction of the autoimmune process that leads to diabetes.
Journal ArticleDOI
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
Joep Grootjans,Joep Grootjans,Niklas Krupka,Niklas Krupka,Shuhei Hosomi,Shuhei Hosomi,Juan D. Matute,Juan D. Matute,Thomas Hanley,Svetlana Saveljeva,Thomas Gensollen,Jarom Heijmans,Hai Li,Julien P. Limenitakis,Stephanie C. Ganal-Vonarburg,Shengbao Suo,Adrienne M. Luoma,Yosuke Shimodaira,Jinzhi Duan,David Q. Shih,Margaret E. Conner,Jonathan N. Glickman,Gwenny M. Fuhler,Noah W. Palm,Marcel R. de Zoete,C. Janneke van der Woude,Guo-Cheng Yuan,Kai W. Wucherpfennig,Stephan R. Targan,Philip Rosenstiel,Richard A. Flavell,Kathy D. McCoy,Andrew J. Macpherson,Arthur Kaser,Richard S. Blumberg +34 more
TL;DR: It is reported that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation, and observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress.
Journal ArticleDOI
Interleukin-1 Receptor and Caspase-1 Are Required for the Th17 Response in Nitrogen Dioxide–Promoted Allergic Airway Disease
Rebecca A. Martin,Jennifer L. Ather,Lennart K. A. Lundblad,Benjamin T. Suratt,Jonathan E. Boyson,Ralph C. Budd,John F. Alcorn,Richard A. Flavell,Stephanie C. Eisenbarth,Matthew E. Poynter +9 more
TL;DR: It is determined that IL-17A(+) cells were predominately CD4(+)T cell receptor (TCR)β(+) Th17 cells, and that a functional IL-1 receptor was required for Th17, but not Th2, cytokine production after in vitro antigen restimulation of lung cells.
Journal ArticleDOI
Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis
Didi Matza,Abdallah Badou,Mithilesh Kumar Jha,Tim Willinger,Andrey Antov,Shomyseh Sanjabi,Koichi Kobayashi,Vincent T. Marchesi,Richard A. Flavell +8 more
TL;DR: It is demonstrated that desmoyokin (AHNAK1) is expressed in mature CTLs, but not in naive CD8+ T cells, and is critical for calcium entry required for their proper function during immune response, and an AHNAK 1-dependent mechanism controlling calcium entry during CTL effector function is demonstrated.