R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation
Ilona Gutcher,Moses Donkor,Qian Ma,Alexander Y. Rudensky,Alexander Y. Rudensky,Richard A. Flavell,Richard A. Flavell,Ming O. Li +7 more
TL;DR: It is shown that deletion of the Tgfb1 gene from activated T cells and T Reg cells, but not Treg cells alone, abrogated Th17 cell differentiation, resulting in almost complete protection from EAE.
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IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic
Lauren A. Zenewicz,Xiaochen Yin,Guoyang Wang,Eran Elinav,Liming Hao,Liping Zhao,Liping Zhao,Richard A. Flavell +7 more
TL;DR: It is found that healthy IL-22–deficient mice had altered colonic microbiota, notably with decreased abundance of some genera, including Lactobacillus, and increased levels of others, and this altered gut microbiota can be transmitted to cohoused wild-type animals along with the increased susceptibility to this colitis.
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Bacterial flagellin stimulates toll-like receptor 5—dependent defense against vancomycin-resistant Enterococcus infection
Melissa A. Kinnebrew,Carles Ubeda,Lauren A. Zenewicz,Nichole Smith,Richard A. Flavell,Eric G. Pamer +5 more
TL;DR: It is demonstrated that the TLR5 agonist flagellin restores antibiotic-impaired innate immune defenses and restricts colonization with VRE by enhancing mucosal resistance to multidrug-resistant organisms.
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Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.
Till Strowig,Anthony Rongvaux,Chozhavendan Rathinam,Hitoshi Takizawa,Hitoshi Takizawa,Chiara Borsotti,Chiara Borsotti,William M. Philbrick,Elizabeth E. Eynon,Elizabeth E. Eynon,Markus G. Manz,Markus G. Manz,Richard A. Flavell,Richard A. Flavell +13 more
TL;DR: HSIRPa-transgenic Rag2/−γc−/− mice represent a unique mouse strain supporting high levels of human cell engraftment, which can easily be genetically manipulated and improved functionality of the human immune system in these mice.
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A Salmonella protein causes macrophage cell death by inducing autophagy
TL;DR: It is proposed that Salmonella, through the action of SipB, kills macrophages by disrupting mitochondria, thereby inducing autophagy and cell death.