R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
More filters
Journal ArticleDOI
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Maria Carolina Amezcua Vesely,Paris Pallis,Piotr Bielecki,Jun Siong Low,Jun Zhao,Christian C. D. Harman,Lina Kroehling,Ruaidhri Jackson,Will Bailis,Paula Licona-Limón,Hao Xu,Norifumi Iijima,Padmini S. Pillai,Daniel H. Kaplan,Casey T. Weaver,Yuval Kluger,Monika S. Kowalczyk,Akiko Iwasaki,João Pereira,Enric Esplugues,Nicola Gagliani,Nicola Gagliani,Nicola Gagliani,Richard A. Flavell +23 more
TL;DR: It is found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp).
Journal Article
CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.
TL;DR: It is shown that CD40L is not essential for T cell response to TCR engagement if the APC have costimulatory activity, although it is essential forT cell-mediated induction of such costimulation activity.
Journal ArticleDOI
Apoptosis genes and autoimmunity.
David L. Vaux,Richard A. Flavell +1 more
TL;DR: An understanding of the pathophysiology of common autoimmune diseases will require elucidation of many different systems that interact in complex ways, of which the process of apoptosis is just one.
Journal ArticleDOI
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Abigail Jarret,Ruaidhri Jackson,Coco Duizer,Marc E. Healy,Jun Zhao,Joseph M. Rone,Piotr Bielecki,Esen Sefik,Manolis Roulis,Tyler Rice,Kisha N. Sivanathan,Ting Zhou,Angel G. Solis,Hanna Honcharova-Biletska,Karelia Vélez,Saskia Hartner,Saskia Hartner,Jun Siong Low,Rihao Qu,Marcel R. de Zoete,Noah W. Palm,Aaron M. Ring,Achim Weber,Andreas E. Moor,Yuval Kluger,Roni Nowarski,Richard A. Flavell,Richard A. Flavell +27 more
TL;DR: It is shown that neuron-derived IL-18 signaling controls tissue-wide intestinal immunity and has profound consequences on the mucosal barrier and invasive bacterial killing.
Journal ArticleDOI
IL-22 and inflammation: leukin' through a glass onion.
TL;DR: Therapeutics targeting IL‐22, a Th17 T‐cell‐associated cytokine that is highly expressed during chronic inflammation, may have promise for treating various chronic inflammatory diseases.